SMAD2
SMAD family member 2
Synonyms:
JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2
Species:
Human SMAD2 (4087), Mouse Smad2 (17126), Rat Smad2 (29357), dog SMAD2 (480144), domestic cat SMAD2 (101087179), Zebrafish smad2 (30639), chicken SMAD2 (395247), naked mole-rat Smad2 (101714203), domestic guinea pig Smad2 (100726958), sheep SMAD2 (101114231) ...More
UniProtKB ID:
Gene ID:
- Human(4087) Summary: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
- Mouse(17126) SMAD family member 2
- Rat(29357) SMAD family member 2
- dog(480144) SMAD family member 2
- domestic cat(101087179) SMAD family member 2
- Zebrafish(30639) MAD homolog 2 (Drosophila)
- chicken(395247) SMAD family member 2
- naked mole-rat(101714203) SMAD family member 2
- domestic guinea pig(100726958) SMAD family member 2
- sheep(101114231) SMAD family member 2
- sheep(443170) SMAD family member 2
- cow(516010) SMAD family member 2
- Horse(100033843) SMAD family member 2
- Domestic Rabbit(100359137) SMAD family member 2
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-SMAD2/MADH2 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-phospho-SMAD2 (pSer467) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-SMAD2 (Ab-220) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-phospho-Smad2 (pSer250) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
western blot
Anti-phospho-Smad2 (Ser465 Antibody, Ser467), from rabbit,
Species Reactivity
human
Application
immunofluorescence
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Proteins
Product Number
Description
Species
SMAD2, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
esiRNA
Product Number
Description
Species