FGFR4
fibroblast growth factor receptor 4
Synonyms:
CD334, JTK2, TKF
Species:
Human FGFR4 (2264), Mouse Fgfr4 (14186), Rat Fgfr4 (25114), Zebrafish fgfr4 (100000160), domestic guinea pig Fgfr4 (100733523), naked mole-rat Fgfr4 (101700214), Domestic Rabbit FGFR4 (100355275), Horse FGFR4 (100068679), sheep FGFR4 (101120660), cow FGFR4 (317696) ...More
UniProtKB ID:
Gene ID:
- Human(2264) Summary: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008]
- Mouse(14186) fibroblast growth factor receptor 4
- Rat(25114) fibroblast growth factor receptor 4
- Zebrafish(100000160) fibroblast growth factor receptor 4
- domestic guinea pig(100733523) fibroblast growth factor receptor 4
- naked mole-rat(101700214) fibroblast growth factor receptor 4
- Domestic Rabbit(100355275) fibroblast growth factor receptor 4
- Horse(100068679) fibroblast growth factor receptor 4
- sheep(101120660) fibroblast growth factor receptor 4
- cow(317696) fibroblast growth factor receptor 4
- dog(489095) fibroblast growth factor receptor 4
- domestic cat(101100864) fibroblast growth factor receptor 4
- chicken(395603) fibroblast growth factor receptor 4
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-phospho-FGFR4 (pTyr642) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
western blot
Monoclonal Anti-CD334 antibody produced in mouse, clone 4FR6D3,
Species Reactivity
human
Application
flow cytometry
Anti-FGFR4 Antibody, clone 4H2B10B2, ascites fluid, clone 4H2B10B2, from mouse,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Monoclonal Anti-FGFR4 antibody produced in mouse, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-FGFR4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, ab1,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Proteins
Product Number
Description
Species
FGFR4 Protein, active, 10 µg, Active, N-terminal, His6-tagged, recombinant, human FGFR4 amino acids 442-755, for use in Kinase Assays.,
Species
human