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Key Documents

S2442

Sigma-Aldrich

S9 from Liver, Pooled

from human

Synonym(s):

Liver S9 Fraction, S9 Liver Extract

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About This Item

UNSPSC Code:
12161501
NACRES:
NA.47

biological source

human

Quality Level

packaging

vial of ~20 mg

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... RPS9(6203)

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Application

Pooled S9 fractions from liver have been used for genotoxicity experiments.

Biochem/physiol Actions

The hepatic S9 pools from a variety of biological sources represent the post-mitochondrial supernatant fraction from homogenized liver. Known to be a rich source of drug metabolizing enzymes including P-450, these pools are useful in the study of xenobiotic metabolism and drug interactions.
The hepatic S9 pools from a variety of biological sources represent the post-mitochondrial supernatant fraction from homogenized liver. They are known to be a rich source of drug metabolizing enzymes including P-450. S9 pools are useful in the study of xenobiotic metabolism and drug interactions. They are used in the Ames test, which is a method that uses bacteria to test if a given chemical causes mutations in the genetic material of a given test organism.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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The Ames Salmonella/microsome mutagenicity assay.
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An improvement of the Ames test using a modified human liver S9 preparation.
Hakura A
Journal of Pharmacological and Toxicological Methods, 169-172 (2001)

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