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Key Documents

P9764

Sigma-Aldrich

Polydeoxyadenylic acid • Polythymidylic acid sodium salt

double-stranded homopolymer

Synonym(s):

Poly(dA) • Poly(dT)

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About This Item

CAS Number:
86834-22-2
MDL number:
MFCD00131963
UNSPSC Code:
41106305
NACRES:
NA.51

biological source

synthetic (organic)

Quality Level

200

form

powder

storage temp.

−20°C

InChI

1S/C10H14N5O6P.C10H15N2O8P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19;1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19);3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)

InChI key

KKVQVIFXABFJCS-UHFFFAOYSA-N

Application

Polydeoxyadenylic acid • Polythymidylic acid (Poly(dA) • Poly(dT)) is a double-stranded homopolymer use as a DNA model for conformational studies of DNA structure dynamics and drug interaction.

Other Notes

Double-stranded homopolymer

Unit Definition

One unit will yield an A260 of 1.0 in 1.0 ml 20 mM sodium phosphate/100 mM NaCl, pH 7.0

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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R Cao et al.
Journal of biomolecular structure & dynamics, 18(6), 844-856 (2001-07-11)
The DNA binding behavior of a tricationic cyanine dye (DiSC3+(5)) was studied using the [Poly(dA-dT)]2, [Poly(dI-dC)]2 and Poly(dA) x Poly(dT) duplex sequences and the Poly(dA) x 2Poly(dT) triplex. Optical spectroscopy and viscometry results indicate that the dye binds to the
U Sehlstedt et al.
Journal of molecular biology, 278(1), 31-56 (1998-05-26)
The binding of an antiviral quinoxaline derivative, 2,3-dimethyl- 6 - (dimethylaminoethyl) - 9 - hydroxy - 6H - indolo - [2,3 - b]quinoxaline (9-OH-B220), to synthetic double and triple helical DNA (poly(dA).poly(dT) and poly(dA).2poly(dT)) and RNA (poly(rA). poly(rU) and poly
T Ha Duong et al.
Journal of biomolecular structure & dynamics, 14(6), 691-701 (1997-06-01)
DNA-drug complexes are important because of their pharmacological interest but, in addition, they provide a useful model to study the essential aspects of DNA recognition processes. In order to investigate the influence of ligand binding on the dynamic properties of
K M Kosikov et al.
Journal of molecular biology, 289(5), 1301-1326 (1999-06-22)
Computer-simulated elongation and compression of A - and B -DNA structures beyond the range of thermal fluctuations provide new insights into high energy "activated" forms of DNA implicated in biochemical processes, such as recombination and transcription. All-atom potential energy studies
B Gong et al.
Biochemical and biophysical research communications, 240(3), 557-560 (1997-12-17)
New DNA minor-groove binding molecules with high binding affinities and sequence-selectivities are described. The effects of structural changes in ligands with a three-ring backbone on their DNA-binding properties have been studied. Of a pool of eight potential ligands, two showed
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