P7762

Poly-L-arginine hydrochloride

mol wt 15,000-70,000

• Synonym(s): L-Arginine homopolymer hydrochloride
• CAS Number: 26982-20-7
• MDL number: MFCD00166393
• UNSPSC Code: 12352209
• PubChem Substance ID: 24898874
• NACRES: NA.26

Properties

• form: powder
• mol wt: 15,000-70,000
• color: white to off-white
• application(s): cell analysis
• storage temp.: −20°C
• SMILES string: Cl.NC(CCCNC(N)=N)C(O)=O
• InChI: 1S/C18H38N12O4.ClH/c19-10(4-1-7-26-16(20)21)13(31)29-11(5-2-8-27-17(22)23)14(32)30-12(15(33)34)6-3-9-28-18(24)25;/h10-12H,1-9,19H2,(H,29,31)(H,30,32)(H,33,34)(H4,20,21,26)(H4,22,23,27)(H4,24,25,28);1H/t10-,11-,12-;/m0./s1
• InChI key: PQEISBBDIRAKGR-LFELFHSZSA-N

Description

General description

Poly-L-arginine hydrochloride (PLA) is a homopolyamino acid. PLA enhances membrane permeability compared to poly-L-lysine. It has applications as drug carrier, neuroprotective agent and in anticancer vaccines preparations. Peptide vaccines in conjugation with PLA promotes antigen-presenting cells (APCs) to generate T cell and elicit immunostimulant functionality.

Application

Poly-L-arginine hydrochloride has been used:

• to generate complex with stimulatory RNA isRNA9.2 as in neutrophils
• used in ribosomal RNA transfection into human monocytic THP-1 cells
• for coating alginate capsule beads

Quality

Contains 3% or less ornithine residue.

Analysis Note

Molecular weight based on viscosity of precursor poly-L-ornithine. Also assayed by MALLS.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves