L5768

Lanosterol

≥93%, powder

• Synonym(s): 3β-Hydroxy-8,24-lanostadiene, 8,24-Lanostadien-3β-ol
• Empirical Formula (Hill Notation): C₃₀H₅₀O
• CAS Number: 79-63-0
• Molecular Weight: 426.72
• EC Number: 201-214-9
• MDL number: MFCD00021108
• UNSPSC Code: 12352211
• PubChem Substance ID: 24896417
• NACRES: NA.77

Properties

• Assay: ≥93%
• form: powder
• color: white to off-white
• storage temp.: −20°C
• SMILES string: [H][C@@]1(CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](O)C(C)(C)[C@]4([H])CC3)[C@H](C)CC\C=C(/C)C
• InChI: 1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1
• InChI key: CAHGCLMLTWQZNJ-BQNIITSRSA-N

Description

General description

Lanosterol, an amphipathic molecule, that is produced by lanosterol synthase (LSS). It is enriched in the lens.

Application

Lanosterol has been used:

• as a standard in HPLC for the quantification in testis samples
• in S-adenosyl-L-methionine:Δ²⁴-sterol-C-methyltransferase (SMT) assay
• to treat wild-type cells growing in rich medium to know its effects on Sre1 protein

Biochem/physiol Actions

Cholesterol precursor sterol.
Lanosterol serves as an endogenous selective modulator of macrophage immunity.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves