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G0759

Sigma-Aldrich

Sodium glycochenodeoxycholate

Synonym(s):

3α,7α-Dihydroxy-5β-cholanoic acid N-(carboxymethyl)amide sodium salt, Glycochenodeoxycholic acid sodium salt, N-(3α,7α-Dihydroxy-24-oxocholan-24-yl)glycine sodium salt

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About This Item

Empirical Formula (Hill Notation):
C26H42NNaO5
CAS Number:
16564-43-5
Molecular Weight:
471.61
Beilstein:
3847290
MDL number:
MFCD00036743
UNSPSC Code:
12161900
PubChem Substance ID:
24895023
NACRES:
NA.25
Pricing and availability is not currently available.

description

anionic

Quality Level

200

form

powder

mol wt

471.61 g/mol

technique(s)

HPLC: suitable
protein quantification: suitable

functional group

sulfonic acid

shipped in

ambient

storage temp.

room temp

SMILES string

[Na+].C[C@H](CCC(=O)NCC([O-])=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C26H43NO5.Na/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29;/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32);/q;+1/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-;/m1./s1

InChI key

AAYACJGHNRIFCT-YRJJIGPTSA-M

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General description

Glycochenodeoxycholate (GCDC) is a toxic hydrophobic bile salt.

Application

Sodium glycochenodeoxycholate has been used as an additive in de Man, Rogosa and Sharpe (MRS) agar for bile acid deconjugation to determine the capacity of the strains to deconjugate specific bile acids.
Sodium glycochenodeoxycholate has been used in a study to assess the repair of DNA damage induced by bile salts. [1] It has also been used in a study to investigate enterotoxin production by Clostridium perfringens type A in the presence of human bile salts. [2]

Biochem/physiol Actions

Glycochenodeoxycholate (GCDC) can induce hepatocyte apoptosis that is partially mediated by Fas.

replaced by

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000396759
0000396759
0000413704
0000413704
0000410449

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Ana I Prieto et al.
Genetics, 174(2), 575-584 (2006-08-05)
Exposure of Salmonella enterica to sodium cholate, sodium deoxycholate, sodium chenodeoxycholate, sodium glycocholate, sodium taurocholate, or sodium glycochenodeoxycholate induces the SOS response, indicating that the DNA-damaging activity of bile resides in bile salts. Bile increases the frequency of GC -->
Lin Lin et al.
American journal of translational research, 11(6), 3365-3374 (2019-07-18)
Human noroviruses (HuNoVs) are a major cause of epidemic and sporadic cases of acute gastroenteritis worldwide. Recently, human intestinal enteroids (HIEs) have been shown to support the replication of HuNoVs, and be an excellent model to study HuNoV-host interactions. We
Robert L Atmar et al.
The Journal of infectious diseases, 221(5), 739-743 (2019-10-16)
The development of an in vitro cultivation system for human noroviruses allows the measurement of neutralizing antibody levels. Serum neutralizing antibody levels were determined using a GII.4/Sydney/2012-like virus in human intestinal enteroids in samples collected before and 4 weeks after
N L Heredia et al.
FEMS microbiology letters, 68(1), 15-21 (1991-11-01)
The effect of human bile juice and bile salts (sodium cholate, sodium taurocholate, sodium glycochenodeoxycholate and sodium chenodeoxycholate) on growth, sporulation and enterotoxin production by enterotoxin-positive and enterotoxin-negative strains of Clostridium perfringens was determined. Each bile salt inhibited growth to
Hui Wang et al.
Journal of cellular physiology, 235(2), 1615-1623 (2019-07-28)
The incidence of gallbladder cancer (GBC) is relatively rare but a high degree of malignancy. The migration and invasion potential of GBC severely affects the prognosis of patients with GBC. Glycochenodeoxycholate (GCDC) is one of the most important components in
View All Related Papers

Questions

  1. はじめまして、こちらの商品を購入したものです。 パウダー状で、郵送されると思います。液体に溶かして細胞などに添加することを考えております。 溶媒を加え、保存するのに、適した溶媒の種類、保存条件、消費期限などございましたら、ご教授いただければ幸いです。

    1 answer

    1. This product has not been tested for use in cell culture. However, several articles listed in the Peer Reviewed Papers indicate usage in cell culture applications. This material is a hydrophobic compound, soluble in water at 50 mg/ml, as listed on the lot specific Certificate of Analysis. Stock solution may then be diluted in buffer or medium. Solutions should be filter sterilized prior to adding to cultures. The solution stability has not been determined. Several external sources state that a solution of Sodium glycochenodeoxycholate can be stored for 6 months at -80°C and 1 month at 20°C. This information has not been validated. This product does not have an expiration date, but has an assigned retest date. Products that, while considered stable, may be subject to degradation over time are assigned a periodic retest date to confirm quality. The lot specific retest date is reported on the Certificate of Analysis.

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