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456756

Sigma-Aldrich

Iodomethane solution

2.0 M in tert-butyl methyl ether, contains copper as stabilizer

Synonym(s):

Methyl iodide

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About This Item

Empirical Formula (Hill Notation):
CH3I
CAS Number:
Molecular Weight:
141.94
Beilstein:
969135
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.21

vapor pressure

16.85 psi ( 55 °C)
4.86 psi ( 20 °C)

Quality Level

contains

copper as stabilizer

concentration

2.0 M in tert-butyl methyl ether

bp

41-43 °C

density

0.933 g/mL at 25 °C

functional group

alkyl halide
iodo

storage temp.

2-8°C

SMILES string

CI

InChI

1S/CH3I/c1-2/h1H3

InChI key

INQOMBQAUSQDDS-UHFFFAOYSA-N

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General description

The product is 2M solution of iodomethane in tert-butyl methyl ether. Iodomethane also known as methyl iodide is an alkyl halide commonly employed as methylating agent.

Application

  • 8-plex LC-MS/MS Analysis of Permethylated N-Glycans Achieved by Using Stable Isotopic Iodomethane.: This research demonstrates the use of iodomethane in stable isotope labeling for the mass spectrometric analysis of permethylated N-glycans. The method enhances the accuracy and sensitivity of glycomic studies (Dong et al., 2019).
  • Comparative glycomic profiling of isotopically permethylated N-glycans by liquid chromatography/electrospray ionization mass spectrometry.: The study presents a comparative analysis of N-glycan profiles using isotopically labeled iodomethane, improving the resolution and identification of glycan structures in complex biological samples (Hu et al., 2013).
  • Antifungal property of quaternized chitosan and its derivatives.: This paper explores the synthesis of quaternized chitosan derivatives using iodomethane and their subsequent antifungal activities. The results suggest potential applications in biomedical and agricultural fields (Sajomsang et al., 2012).
  • Validation of two fluoro-analogues of N,N-dimethyl-2-(2′-amino-4′-hydroxymethyl-phenylthio)benzylamine as serotonin transporter imaging agents using microPET.: This research validates fluoro-analogues of a serotonin transporter imaging agent, synthesized using iodomethane, highlighting its potential in neuroimaging applications (Jarkas et al., 2010).

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Irrit. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

-0.4 °F

Flash Point(C)

-18 °C


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Selective mono-methylation of arylacetonitriles and methyl arylacetates by dimethyl carbonate.
Selva M, et al.
Journal of the Chemical Society. Perkin Transactions 1, 10, 1323-1328 (1994)
Xiao-Dan Shi et al.
Food chemistry, 271, 338-344 (2018-09-22)
Dictyophora echinovolvata is a kind of edible mushroom in the Dictyophora genus, of which polysaccharide is an important chemical substance. Herein, three polysaccharide fractions (DEP-4P, DEP-6P and DEP-8P) were prepared from water extract of D. echinovolvata using gradient ethanol precipitation
Riet Bammens et al.
Glycobiology, 25(6), 669-682 (2015-01-23)
The congenital disorders of glycosylation (CDG), a group of inherited diseases characterized by aberrant glycosylation, encompass a wide range of defects, including glycosyltransferases, glycosidases, nucleotide-sugar transporters as well as proteins involved in maintaining Golgi architecture, pH and vesicular trafficking. Mutations
Warayuth Sajomsang et al.
International journal of biological macromolecules, 50(1), 263-269 (2011-11-22)
Five water-soluble chitosan derivatives were carried out by quaternizing either iodomethane or N-(3-chloro-2-hydroxypropyl) trimethylammonium chloride (Quat188) as a quaternizing agent under basic condition. The degree of quaternization (DQ) ranged between 28±2% and 90±2%. The antifungal activity was evaluated by using
R Otto et al.
Nature chemistry, 4(7), 534-538 (2012-06-22)
Solvents have a profound influence on chemical reactions in solution and have long been used to control their outcome. Such effects are generally considered to be governed by thermodynamics; however, little is known about the steric effects of solvent molecules.

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