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03880590

Luteolin

primary reference standard

Synonym(s):

3′,4′,5,7-Tetrahydroxyflavone

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About This Item

Empirical Formula (Hill Notation):
C15H10O6
CAS Number:
491-70-3
Molecular Weight:
286.24
Beilstein:
292084
EC Number:
207-741-0
MDL number:
MFCD00017309
UNSPSC Code:
85151701
PubChem Substance ID:
329747828
NACRES:
NA.24

grade

primary reference standard

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

HWI

mp

~330 °C (lit.)

application(s)

food and beverages

SMILES string

Oc1cc(O)c2C(=O)C=C(Oc2c1)c3ccc(O)c(O)c3

InChI

1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H

InChI key

IQPNAANSBPBGFQ-UHFFFAOYSA-N

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General description

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

Application

Reference Standard in the analysis of herbal medicinal products

Other Notes

This compound is commonly found in plants of the genus: achillea

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
HWI03169-1
HWI03169
HWI02485-1
HWI02485
HWI02293

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Benguo Liu et al.
Food chemistry, 141(2), 900-906 (2013-06-26)
The formation of supramolecular inclusion complexes between luteolin and five cyclodextrins namely β-cyclodextrin (β-CD), methyl-β-cyclodextrin (M-β-CD), hydroxyethyl-β-cyclodextrin (HE-β-CD), hydroxypropyl-β-cyclodextrin (HP-β-CD) and glucosyl-β-cyclodextrin (G-β-CD) was investigated. Results from phase-solubility studies showed that luteolin formed 1:1 stoichiometric inclusion complexes with these cyclodextrins
Chithan Kandaswami et al.
In vivo (Athens, Greece), 19(5), 895-909 (2005-08-16)
The flavonoids are polyphenolic compounds found as integral components of the human diet. They are universally present as constituents of flowering plants, particularly of food plants. The flavonoids are phenyl substituted chromones (benzopyran derivatives) consisting of a 15-carbon basic skeleton
Poyil Pratheeshkumar et al.
PloS one, 7(12), e52279-e52279 (2013-01-10)
Angiogenesis, the formation of new blood vessels from pre-existing vascular beds, is essential for tumor growth, invasion, and metastasis. Luteolin is a common dietary flavonoid found in fruits and vegetables. We studied the antiangiogenic activity of luteolin using in vitro
Lien Verschooten et al.
PloS one, 7(10), e48264-e48264 (2012-10-31)
Flavonoids are widely proposed as very interesting compounds with possible chemopreventive and therapeutic capacities. In this study, we showed that in vitro treatment with the flavonoid Luteolin induced caspase-dependent cell death in a model of human cutaneous squamous cell carcinoma
Sung Wook Park et al.
Investigative ophthalmology & visual science, 53(12), 7718-7726 (2012-10-27)
Oxidative stress-induced vascular endothelial growth factor (VEGF) is thought to play a critical role in the pathogenesis of retinopathy of prematurity (ROP). This study was performed to investigate the anti-angiogenic effect of luteolin against reactive oxygen species (ROS)-induced retinal neovascularization.
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