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840875P

Avanti

18:1 PA

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate (sodium salt); DOPA; PA(18:1(9Z)/18:1(9Z))

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About This Item

Empirical Formula (Hill Notation):
C39H72O8PNa
CAS Number:
108392-02-5
Molecular Weight:
722.95
UNSPSC Code:
51191904
NACRES:
NA.25

description

1,2-dioleoyl-sn-glycero-3-phosphate (sodium salt)

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g (840875P-1g)
pkg of 2 × 100 mg (840875P-200mg)
pkg of 5 × 100 mg (840875P-500mg)
pkg of 1 × 25 mg (840875P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(O)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[Na+]

General description

18:1 PA (1,2-dioleoyl-sn-glycero-3-phosphate (sodium salt)) is an anionic lipid.

Application

18:1 PA (1,2-dioleoyl-sn-glycero-3-phosphate (sodium salt)):
  • may be used in liposomes for liposome leakage assay
  • may be used to create liposome template to synthesize calcium phosphate (CaP) nanoshells
  • may be used as a component in liposomes/lipid bilayers
  • has been used an additive in the medium of neuron-glia mixed culture to study the effects of astrocyte phospholipase D1 (PLD1) on dendritic branching
  • has been used in chemiluminescent assay of cytochrome c Trp59

Biochem/physiol Actions

Phosphatidic acid (PA) acts as a lipid messenger.

Packaging

5 mL Clear Glass Sealed Ampule (840875P-200mg)
5 mL Clear Glass Sealed Ampule (840875P-25mg)
5 mL Clear Glass Sealed Ampule (840875P-500mg)
60 mL Amber Wide Mouth Screw Cap Glass Bottle (840875P-1g)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Comparison of DOPA and DPPA liposome templates for the synthesis of calcium phosphate nanoshells
Yeo CH, et al.
Ceramics International, 38(1), 561-570 null
Xinhui Sun et al.
Cell cycle (Georgetown, Tex.), 14(5), 721-731 (2015-01-16)
It had been known for decades that primordial follicles in mammalian ovaries are assembled with definite numbers and represent the ovarian reserve throughout the reproductive life. Intra-oocyte PI3K/mTOR pathways have been indicated to play a central role on the activation
Shutao Guo et al.
Journal of controlled release : official journal of the Controlled Release Society, 174, 137-142 (2013-11-28)
The poor solubility of cisplatin (CDDP) often presents a major obstacle in the formulation of CDDP in nanoparticles (NPs) by traditional methods. We have developed a novel method for synthesizing CDDP NPs taking advantage of its poor solubility. By mixing
Kathleen Frondorf et al.
The Journal of biological chemistry, 285(21), 15837-15847 (2010-03-23)
Phosphatidic acid (PA) is a pleiotropic lipid second messenger in mammalian cells. We report here that extracellular PA acts as a leukocyte chemoattractant, as membrane-soluble dioleoyl-PA (DOPA) elicits actin polymerization and chemotaxis of human neutrophils and differentiated proleukemic HL-60 cells.
Zhenhua Hu et al.
Science advances, 6(14), eaba0145-eaba0145 (2020-04-10)
Low oral bioavailability of peptide drugs has limited their application to parenteral administration, which suffers from poor patient compliance. Here, we show that molecular targeting of the FATP4 transporter is an effective approach to specifically transport long-chain fatty acid (LCFA)-conjugated
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