764779
Poly(ethylene glycol) methyl ether-block-poly(D,L lactide)
PEG average Mn 2,000, PDLLA average Mn 2,000
Synonym(s):
PEG-PDLLA
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
UNSPSC Code:
12162002
NACRES:
NA.23
Recommended Products
description
n=45, m=28 (typical)
typical PEG PDI<1.1; overall PDI<1.4 (THF, PEO)
form
pellets
mol wt
PDLLA average Mn 2,000
PEG average Mn 2,000
average Mn 4,000 (total)
degradation timeframe
2-4 weeks
transition temp
Tg 11 °C (PEG block)
Tm 244-248 °C
Tg 88 °C (PDLLA block)
PDI
≤1.4
storage temp.
2-8°C
General description
Block copolymer micelles are widely used in drug delivery applications. PEG-PDLLA is a biodegradable polymeric micelle which is used as carriers for hydrophobic drugs like paclitaxel. PEG is the hydrophilic part and PDLLA is the hydrophobic part which forms the micelle core wherein the hydrophobic drug is loaded.
Application
Used as a carrier for the controlled and targeted release of anticancer hydrophobic drugs.
water-solubilization of drugs
Features and Benefits
- Good biocompatibility, low immunogenicity and good degradability.
- Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
Hongtao Chen et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(18), 6596-6601 (2008-05-01)
It is generally assumed that polymeric micelles, upon administration into the blood stream, carry drug molecules until they are taken up into cells followed by intracellular release. The current work revisits this conventional wisdom. The study using dual-labeled micelles containing
Arunvel Kailasan et al.
Acta biomaterialia, 6(3), 1131-1139 (2009-09-01)
This work describes the synthesis and characterization of novel thermoresponsive highly branched polyamidoamine-polyethylene glycol-poly(D,L-lactide) (PAMAM-PEG-PDLLA) core-shell nanoparticles. A series of dendritic PEG-PDLLA nanoparticles were synthesized through conjugation of PEG of various chain lengths (1500, 6000 and 12,000 g mol(-1)) to
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service