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404322

Sigma-Aldrich

Dichloro(1,2-diaminocyclohexane)platinum(II)

Synonym(s):

(1,2-Diaminocyclohexane)platinum(II) chloride

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About This Item

Linear Formula:
[C6H10(NH2)2]PtCl2
CAS Number:
52691-24-4
Molecular Weight:
380.17
MDL number:
MFCD00058826
UNSPSC Code:
12161600
PubChem Substance ID:
24865237
NACRES:
NA.22

Quality Level

100

reaction suitability

core: platinum
reagent type: catalyst

mp

280 °C (dec.) (lit.)

SMILES string

Cl[Pt]Cl.NC1CCCCC1N

InChI

1S/C6H14N2.2ClH.Pt/c7-5-3-1-2-4-6(5)8;;;/h5-6H,1-4,7-8H2;2*1H;/q;;;+2/p-2

InChI key

PNNCIXRVXCLADM-UHFFFAOYSA-L

Pictograms

Health hazardCorrosion
GHS08,GHS05

Signal Word

Danger

Hazard Classifications

Carc. 2 - Eye Dam. 1 - Lact. - Muta. 2 - Repr. 1B - Resp. Sens. 1B - Skin Sens. 1 - STOT RE 1

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCS6465
MKCH0904
MKBX4372V
MKBS5387V
MKBD2991V

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Horacio Cabral et al.
Journal of controlled release : official journal of the Controlled Release Society, 101(1-3), 223-232 (2004-12-14)
Block copolymer micelles, containing dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt), the oxaliplatin parent complex, were prepared through polymer-metal complex formation of DACHPt with poly(ethylene glycol)-poly(glutamic acid) block copolymer [PEG-P(Glu)] in distilled water. By dynamic light scattering (DLS) measurement, the micelle size was determined to
Y Kido et al.
Biochemical pharmacology, 47(9), 1635-1642 (1994-04-29)
Tetraplatin (Ormaplatin) has good antitumor activity against some cisplatin-resistant cells and is currently being studied in clinical trials. We have studied the effect of extracellular reduced glutathione (GSH) on the cytotoxicity and biochemical pharmacology of tetraplatin in L1210 leukemia cells.
Md Rafi et al.
Journal of controlled release : official journal of the Controlled Release Society, 159(2), 189-196 (2012-02-14)
Nano-scaled drug carriers have great potential for the treatment of solid tumors. Nevertheless, hypovascularity and fibrosis in some types of solid tumors have been demonstrated to reduce the penetration and accumulation of nano-scaled drug carriers. Diffuse-type scirrhous gastric cancers present
S K Mauldin et al.
Cancer research, 48(18), 5136-5144 (1988-09-15)
We have previously reported the development of a two-column high performance liquid chromatography system for separation of platinum(II) complexes with the 1,2-diaminocyclohexane (DACH) carrier ligand (Mauldin et al., Anal. Biochem., 157: 129, 1986). Here we report the application of this
F Grolleau et al.
Journal of neurophysiology, 85(5), 2293-2297 (2001-05-16)
Oxaliplatin, a new widely used anticancer drug, displays frequent, sometimes severe, acute sensory neurotoxicity accompanied by neuromuscular signs that look like the symptoms observed in tetany and myotonia. The whole cell patch-clamp technique was employed to investigate the oxaliplatin effects
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