1457833

Nebivolol hydrochloride

United States Pharmacopeia (USP) Reference Standard

• Synonim(y): Narbivolol, Nebilet, R-65824, rel-(aR,a′R,2R,2′S)-a,a′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride
• Wzór empiryczny (zapis Hilla): C₂₂H₂₅F₂NO₄ · HCl
• Numer CAS: 152520-56-4
• Masa cząsteczkowa: 441.90
• Kod UNSPSC: 41116107
• NACRES: NA.24

Właściwości

• klasa czystości: pharmaceutical primary standard
• rodzina API: nebivolol
• producent / nazwa handlowa: USP
• Zastosowanie: pharmaceutical
• format: neat
• temp. przechowywania: 2-8°C
• ciąg SMILES: Cl.O[C@@H](CNC[C@H](O)[C@@H]1CCc2cc(F)ccc2O1)[C@H]3CCc4cc(F)ccc4O3
• InChI: 1S/C22H25F2NO4.ClH/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22;/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2;1H/t17-,18-,21-,22+;/m0./s1
• Klucz InChI: JWEXHQAEWHKGCW-BIISKSHESA-N

Opis

Opis ogólny

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Zastosowanie

Nebivolol hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Działania biochem./fizjol.

Nebivolol is a competitive, highly selective b1-receptor antagonist with mild vasodialating properties, possibly due to an interaction with the L-arginine/ NO pathway, and is used for treatment of essential hypertension. It is 40-fold selective for β1 vs. β2, and lacks ISA (intrinsic sympathomimetic activity).

Komentarz do analizy

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Inne uwagi

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3