1294820

Glutation

United States Pharmacopeia (USP) Reference Standard

• Synonim(y): L-Glutathione reduced, γ-L-Glutamyl-L-cysteinyl-glycine, GSH
• Wzór liniowy: H₂NCH(CO₂H)CH₂CH₂CONHCH(CH₂SH)CONHCH₂CO₂H
• Numer CAS: 70-18-8
• Masa cząsteczkowa: 307.32
• Beilstein: 1729812
• Numer MDL: MFCD00065939
• Kod UNSPSC: 41116107
• Identyfikator substancji w PubChem: 329749948
• NACRES: NA.24

Właściwości

• klasa czystości: pharmaceutical primary standard
• rodzina API: glutathione
• producent / nazwa handlowa: USP
• mp: 192-195 °C (dec.) (lit.)
• Zastosowanie: pharmaceutical (small molecule)
• Format: neat
• ciąg SMILES: N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O
• InChI: 1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1
• Klucz InChI: RWSXRVCMGQZWBV-WDSKDSINSA-N

Opis

Amino Acid Sequence

γ-Glu-Cys-Gly

Opis ogólny

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Zastosowanie

May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.

Działania biochem./fizjol.

Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents.

Komentarz do analizy

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Inne uwagi

Sales restrictions may apply.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable