W2020

WR-1065

≥98% (HPLC), reactive oxygen species scavenger, powder

• Synonim(y): 2-[(3-Aminopropyl)amino]ethanethiol dihydrochloride, WR-1065 dihydrochloride
• Wzór empiryczny (zapis Hilla): C₅H₁₄N₂S · 2HCl
• Numer CAS: 14653-77-1
• Masa cząsteczkowa: 207.16
• UNSPSC Code: 12352200
• PubChem Substance ID: 329830444
• NACRES: NA.77
• MDL number: MFCD00460339
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Właściwości

• Nazwa produktu: WR-1065, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to off-white
• solubility: H₂O: ≥20 mg/mL
• storage temp.: −20°C
• SMILES string: Cl.Cl.NCCCNCCS
• InChI: 1S/C5H14N2S.2ClH/c6-2-1-3-7-4-5-8;;/h7-8H,1-6H2;2*1H
• InChI key: XDRLRDHLCIFZIW-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

WR-1065 is a cytoprotective cell-permeable ROS scavenge and an active metabolite of Amifostine.

WR-1065 is cytoprotective cell-permeable reactive oxygen species scavenger and p53 activator and re-activator. Recently shown to have antiretroviral activity and an active metabolite of Amifostine which selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy.

WR-1065 is the active metabolite of the prodrug amifostine, generated by alkaline phosphatase. It is found to accumulate in many epithelial tissues. WR-1065 protects cellular membranes and DNA from free radical induced damage.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS05,GHS07
• signalword: Danger
• hcodes: H302,H318
• pcodes: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable