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T8944
Topoisomerase II α human
(Single band on SDS-PAGE), liquid
Synonim(y):
Topoisomerase II alpha, TOPO® II, p170
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 100 units | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 2440,00 zł |
Informacje o tej pozycji
2440,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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Pozwól nam pomócQuality Level
form
liquid
mol wt
170 kDa
UniProt accession no.
storage temp.
−70°C
Gene Information
human ... TOP2A(7153)
General description
Topoisomerase II α (TopoIIα) is a gene product with conserved catalytic activities and it promotes the progression of DNA damage. The α isoform is present in proliferating cells. [1]
Topoisomerase II α is encoded by TOP2A gene, which is located on 17q21.2 in the human chromosome. It is essential for controlling the topological state of DNA by reversibly breaking the DNA strands during replication, recombination and transcription. TOP2A expression increases at late S phase and during G2/M of the cell cycle and decreases after mitosis. Polymorphism with TOP2A causes chromosome instability and tumorigenesis. TOP2A causes tumor proliferation and invasiveness in various cancer types like breast cancer, ovarian cancer and prostate cancer.
Application
Human topoisomerase II α has been used in DNA cleavage assay.[2]
Biochem/physiol Actions
Used to study DNA structure and topology.
Physical form
Buffered aqueous glycerol solution, containing Trizma buffer (pH 7.7). Other components are present in the solution, and lot-specific information on these components may be obtained from Technical Service.
Preparation Note
Recombinant enzyme overexpressed in a proprietary eukaryotic cell line.
Other Notes
One unit will decatenate 0.2 μg of kinetoplast DNA in 30 minutes at 37°C.
Legal Information
TOPO is a registered trademark of Life Technologies
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Ta pozycja | |||
|---|---|---|---|
| Gene Information human ... TOP2A(7153) | Gene Information human ... TOP2A(7153) | Gene Information human ... TOP2A(7153) | Gene Information human ... TOP2A(7153) |
| form liquid | form buffered aqueous solution | form - | form buffered aqueous glycerol solution |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| storage temp. −70°C | storage temp. −20°C | storage temp. - | storage temp. −20°C |
| mol wt 170 kDa | mol wt - | mol wt - | mol wt - |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
Klasa składowania
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Powiązane treści
Instructions
J R Spitzner et al.
Nucleic acids research, 16(12), 5533-5556 (1988-06-24)
Topoisomerase II, purified from chicken erythrocytes, was reacted with a large number of different DNA fragments and cleavages were catalogued in the presence and absence of drugs that stabilize the cleavage intermediate. Cleavages were sequenced to derive a consensus for
TOP2A induces malignant character of pancreatic cancer through activating beta-catenin signaling pathway.
Pei YF, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1864(1), 197-207 (2018)
Maryjean Pendleton et al.
Annals of the New York Academy of Sciences, 1310, 98-110 (2014-02-06)
Type II topoisomerases are essential enzymes that modulate DNA under- and overwinding, knotting, and tangling. Beyond their critical physiological functions, these enzymes are the targets for some of the most widely prescribed anticancer drugs (topoisomerase II poisons) in clinical use.
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| T8944-100UN | 04061833632529 |