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T7329

Sigma-Aldrich

Taurolidine

>97% (NMR), powder

Synonim(y):

4,4′-Methylenebis(tetrahydro-1,2,4-sulfadiazine 1,1-dioxide), Taurolin, Tauroline

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About This Item

Wzór empiryczny (zapis Hilla):
C7H16N4O4S2
Numer CAS:
19388-87-5
Masa cząsteczkowa:
284.36
Numer WE:
243-016-5
Numer MDL:
MFCD00865076
Kod UNSPSC:
12352200
Identyfikator substancji w PubChem:
329826864
NACRES:
NA.77

Próba

>97% (NMR)

Postać

powder

warunki przechowywania

protect from light

kolor

white to off-white

rozpuszczalność

DMSO: >20 mg/mL

temp. przechowywania

room temp

ciąg SMILES

O=S1(=O)CCN(CN1)CN2CCS(=O)(=O)NC2

InChI

1S/C7H16N4O4S2/c12-16(13)3-1-10(5-8-16)7-11-2-4-17(14,15)9-6-11/h8-9H,1-7H2

Klucz InChI

AJKIRUJIDFJUKJ-UHFFFAOYSA-N

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Działania biochem./fizjol.

Taurolidine is a broad spectrum antibiotic with antineoplastic activity, which induces apoptosis and decreases tumor cell proliferation. Taurolidine has been used with TNF-related-apoptosis-inducing ligand (TRAIL) to characterize synergistic responses in many apoptosis related signaling-proteins. Tauroline is also being used as a tool to study the various mechanisms of apoptosis and necrosis.
Taurolidine is an antibacterial agent that can be used for the treatment of peritonis. It has also been used as an antiendoxic substance for systematic inflammatory response syndrome and as an anti-angiogenic agent for tumors. Furthermore, studies have reported that taurolidine can be used for the prevention of multiple catheter-related bloodstream infections.

Uwaga dotycząca przygotowania

Taurolidine is soluble in DMSO at a concentration that is greater than 20 mg/ml.
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

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Odwiedź Bibliotekę dokumentów

Justyna Schubert et al.
Scientific reports, 10(1), 10341-10341 (2020-06-27)
For decades, intraperitoneal chemotherapy (IPC) was delivered into the abdominal cavity as a liquid solution. This preliminary study aims to evaluate foam as a potential new drug carrier for IPC delivery. Foam-based intraperitoneal chemotherapy (FBIC) was produced with taurolidine, hydrogen
Christoph A Jacobi et al.
Anti-cancer drugs, 16(9), 917-921 (2005-09-16)
Taurolidine [bis(1,1-dioxoperhydro-1,2,4-thiadiazinyl-4)-methane (TRD)], a product derived from the aminosulfoacid taurin, was first described as an anti-bacterial substance. It was mainly used in the treatment of patients with peritonis as well as antiendoxic agent in patients with systematic inflammatory response syndrome.
Mette Møller Handrup et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 120(10), 794-801 (2012-09-11)
Taurolidine has demonstrated inhibition of biofilm formation in vitro. The aim of this study was to compare the effect of catheter locking with taurolidine vs heparin in biofilm formation in central venous catheters. Forty-eight children with cancer were randomized to
Kevin Marley et al.
BMC veterinary research, 9, 15-15 (2013-01-22)
Osteosarcoma (OS) affects over 8000 dogs/year in the United States. The disease usually arises in the appendicular skeleton and metastasizes to the lung. Dogs with localized appendicular disease benefit from limb amputation and chemotherapy but most die within 6-12 months
ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Venous access.
S Kolaček et al.
Clinical nutrition (Edinburgh, Scotland), 37(6 Pt B), 2379-2391 (2018-07-30)
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