T7004

Thymidine 5′-monophosphate disodium salt hydrate

≥99%

• Synonim(y): 5′-Thymidylic acid disodium salt, TMP, dTMP
• Wzór empiryczny (zapis Hilla): C₁₀H₁₃N₂Na₂O₈P · xH₂O
• Numer CAS: 33430-62-5
• Masa cząsteczkowa: 366.17 (anhydrous basis)
• UNSPSC Code: 41106305
• NACRES: NA.51
• PubChem Substance ID: 329826857
• EC Number: 251-518-0
• Beilstein/REAXYS Number: 4086927
• MDL number: MFCD09039259
• Assay: ≥99%
• Biological source: synthetic (organic)
• Form: powder
• Solubility: H₂O: 100 mg/mL to clear, colorless
• Storage temp.: −20°C

Właściwości

• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥99%
• form: powder
• solubility: H₂O: 100 mg/mL to clear, colorless
• storage temp.: −20°C
• SMILES string: O.[Na+].[Na+].CC1=CN([C@H]2C[C@H](O)[C@@H](COP([O-])([O-])=O)O2)C(=O)NC1=O
• InChI: 1S/C10H15N2O8P.2Na.H2O/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18;;;/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18);;;1H2/q;2*+1;/p-2/t6-,7+,8+;;;/m0.../s1
• InChI key: KCOPAVKVHIWPKB-SPSULGLQSA-L

Opis

General description

Thymidine 5′-monophosphate de novo synthesis from deoxyuridine monophosphate (dUMP) is catalyzed by the enzyme thymidylate synthase.

Application

Thymidine 5′-monophosphate disodium salt hydrate has been used as a standard for the quantification of metabolites from plasma and tumor interstitial fluid using liquid chromatography-mass spectrometry analysis (LC/MS). It has also been used as a single deoxy-mononucleotide to test its effect on the cell growth of human malignant intestinal CaCo-2 cells and normal rat intestinal cell line IEC-6 cells.[1]

Thymidine 5′-monophosphate disodium salt hydrate has been used as a standard solution.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)