T3202

Torsemide

≥98% (HPLC), solid

• Synonim(y): Demadex, N-[[(1-Methylethyl)amino]carbonyl]-4-[(3-methylphenyl)amino]-3-pyridinesulfonamide
• Wzór empiryczny (zapis Hilla): C₁₆H₂₀N₄O₃S
• Numer CAS: 56211-40-6
• Masa cząsteczkowa: 348.42
• NACRES: NA.77
• PubChem Substance ID: 329826741
• UNSPSC Code: 12352200
• MDL number: MFCD00866166
• Assay: ≥98% (HPLC)
• Form: solid

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• solubility: DMSO: soluble 18 mg/mL, H₂O: insoluble
• originator: Roche
• SMILES string: CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2
• InChI: 1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)
• InChI key: NGBFQHCMQULJNZ-UHFFFAOYSA-N
• Gene Information: human ... SLC12A1(6557)

Opis

Application

Torsemide has been used as an inhibitor of Na⁺ Cl^- co-transporter in transgenic Arabidopsis thaliana plants¹.

Biochem/physiol Actions

Torsemide functions in the thick ascending limb of the loop of Henle and enhances the excretion of sodium, chloride and water from the luminal side of the cells. Furthermore, torsemide can treat oedematous conditions that are associated with diseases such as liver cirrhosis, kidney disorders and chronic congestive heart failure².

Torsemide is a loop diuretic and inhibitor of the Na⁺/K⁺/2Cl^- carrier system.

Torsemide is a loop diuretic of the pyridine-sulfonylurea class with antialdosteronergic properties and inhibitor of the Na⁺/K⁺/2Cl^- carrier system.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Torsemide is soluble in DMSO at 18 mg/ml and is insoluble in water.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H319,H361fd
• pcodes: P201 - P202 - P264 - P280 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Eye Irrit. 2 - Repr. 2
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves