T2896

Triflupromazine hydrochloride

• Synonim(y): N,N-Dimethyl-2-(trifluoromethyl)-10H-phenothiazine-10-propanamine monohydrochloride
• Wzór empiryczny (zapis Hilla): C₁₈H₁₉F₃N₂S · HCl
• Numer CAS: 1098-60-8
• Masa cząsteczkowa: 388.88
• EC Number: 214-149-6
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278730
• Beilstein/REAXYS Number: 3801519
• MDL number: MFCD00058103

Właściwości

• SMILES string: Cl.CN(C)CCCN1c2ccccc2Sc3ccc(cc13)C(F)(F)F
• InChI: 1S/C18H19F3N2S.ClH/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H
• InChI key: FTNWXGFYRHWUKG-UHFFFAOYSA-N
• Gene Information: human ... DRD2(1813)

Opis

Application

Triflupromazine hydrochloride has been used for the screening of inhibitors of S. mansoni miracidial transformation⁵. It has also been used to study its intracellular localization in central nervous system cells using secondary ion mass spectrometry microscopy⁶.

Biochem/physiol Actions

Triflupromazine is a D₂ dopamine antagonist and a phenothiazine antipsychotic. It is also a potent tranquilizer⁷ and can significantly reduce body temperature⁸.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H312 + H332
• pcodes: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves