T2400
Tropomyosin from porcine muscle
lyophilized powder (contains Tris buffer salts)
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About This Item
Polecane produkty
pochodzenie biologiczne
Porcine muscle
Poziom jakości
Próba
≥70% protein basis (biuret)
Postać
lyophilized powder (contains Tris buffer salts)
metody
electrophoresis: suitable
temp. przechowywania
−20°C
Opis ogólny
Tropomyosin is a member of the actin filament binding protein family. It is a ubiquitous protein present in animals and fungi. Tropomyosin is made up of two α-helical chains arranged as a coiled-coil. It exists over twenty isoforms, in different eukaryotic cells like skeletal, cardiac, and smooth muscles, brain, platelets, fibroblasts, platelets, and other non-muscle cells.
Zastosowanie
Tropomyosin from porcine muscle has been used:
- as a positive control in actin- α-tropomyosin (TPM1) co-sedimentation analysis and assay
- in analyzing the anti-adhesive properties of fish tropomyosins
- in far Western blot analysis
Działania biochem./fizjol.
Tropomyosin is associated with the actin cytoskeleton and plays a role in stabilizing and regulating the interactions of actin with other actin-binding proteins. It also plays a role in muscle contraction by regulating the interactions of actin with myosin.
Tropomyosin together with troponin, regulates the binding of myosin to actin. Tropomyosin is a dimeric coiled-coil protein forming continuous polymers along the myosin-binding groove of actin. Various tropomyosin isoforms help confer structure and function to actins in the cytoskeleton and striated muscle function. Dimeric protein that assumes an α-helical coiled-coil conformation. In the absence of Ca2+, it inhibits muscle contractility by blocking the myosin binding sites on actin.
Komentarz do analizy
SDS electrophoresis shows two major bands.
Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
Certyfikaty analizy (CoA)
Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Vertebrate tropomyosin: distribution, properties and function
Perry S V, et al.
Journal of Muscle Research and Cell Motility, 5?49-5?49 (2001)
The molecular basis for tropomyosin isoform diversity
James P L M, et al.
Bioessays (1991)
A systematic nomenclature for mammalian tropomyosin isoforms
Michael A G, et al.
Journal of Muscle Research and Cell Motility, 147?153-147?153 (2015)
A novel alpha-tropomyosin mutation associates with dilated and non-compaction cardiomyopathy and diminishes actin binding
Judith B A, et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 1833(4), 833-839 (2013)
G Reese et al.
International archives of allergy and immunology, 119(4), 247-258 (1999-09-04)
Among food allergens, crustaceans, such as shrimp, crab, crawfish and lobster, are a frequent cause of adverse food reactions in allergic individuals. The major allergen has been identified as the muscle protein tropomyosin. This molecule belongs to a family of
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