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T1500

Testosterone

≥98%

Synonim(y):

17β-Hydroxy-3-oxo-4-androstene, 17β-Hydroxy-4-androsten-3-one, 4-Androsten-17β-ol-3-one, trans-Testosterone

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C19H28O2
Numer CAS:
58-22-0
Masa cząsteczkowa:
288.42
UNSPSC Code:
51111800
NACRES:
NA.77
PubChem Substance ID:
24899970
EC Number:
200-370-5
Beilstein/REAXYS Number:
1915399
MDL number:
MFCD00003654
Assay:
≥98%
Form:
powder
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biological source

synthetic (organic)

Quality Segment

200

sterility

non-sterile

assay

≥98%

form

powder

drug control

USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 18.2 mg/ml, absolute ethanol: soluble 0.5 mg/ml, chloroform: soluble 100 mg/mL, clear, colorless to very faintly yellow, H2O: insoluble, dioxane: soluble, methanol: soluble, methyl oleate: slightly soluble, vegetable oils: soluble

shipped in

ambient

storage temp.

room temp

SMILES string

C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O

InChI

1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1

InChI key

MUMGGOZAMZWBJJ-DYKIIFRCSA-N

Gene Information

human ... AR(367), EBP(10682), ESR1(2099), PGR(5241), SERPINA6(866), SHBG(6462)
mouse ... Esr1(13982)
rat ... Ar(24208), Esr1(24890), Nr3c1(24413), Nr3c2(25672), Pgr(25154)

Application

Testosterone has been used as a standard to study the developmental profile of steroid hormones in male and female rat brains[1]. This hormone has also been used to evaluate its effects on muscle mass and signaling in mice[2].

Biochem/physiol Actions

Testosterone secreted by the testis is converted to dihydrotestosterone in the target tissues where it appears to mediate many of the biological actions of testosterone. Androgens direct the development of the male phenotype during embryogenesis and at puberty.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Testosterone dissolves in chloroform at 100 mg/ml to yield a clear, colorless to very faint yellow solution. It is also soluble in methanol, absolute ethanol (0.5 mg/ml), 45 percent (w/v) aqueous 2-hydroxypropyl-b-cyclodextrin (18.2 mg/ml), vegetable oils and dioxane. It is slightly soluble in methyl oleate and insoluble in water.
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Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Carc. 2 - Repr. 1B

Klasa składowania

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certyfikaty analizy (CoA)

Lot/Batch Number

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Questions

1–6 of 6 Questions  

  1. What can I use to prepare a solution of Product T1500, Testosterone?

    1 answer

    1. The product is soluble in absolute ethanol (0.5 mg/ml), It is also soluble in vegetable oils, soluble in dioxan and slightly soluble in methyl oleate.

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  2. It is possible to sterile filter a solution of Product T1500, Testosterone?

    1 answer

    1. A solution of testosterone cannot be sterile filtered, since the compound will stick to the filter paper, according to Sigma cell culture scientists' experience.

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  3. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  4. What is the method of production for Product T1500, Testosterone?

    1 answer

    1. This information is listed on the product's Certificate of Origin, which is lot-specific and, thus, subject to change. Enter the lot number of interest into the Certificate of Origin search box on the product page to find this information.

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  5. How long can I store a solution of Product T1500, Testosterone?

    1 answer

    1. We have not determined the solution stability of this product. As a guideline, please note the stability of product no. T5411, Testosterone solution 1.0 mg/mL, which is stable for  3 years at 2-8 C.

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  6. How could I dissolve Product T1500, Testosterone for cell culture use?

    1 answer

    1. This product has not been tested for cell culture use. We offered Testosterone for cell culture, now discontinued, and for it our 1998 Sigma Cell Culture advised to dissolve 1 mg in 2.0 mL absolute ethanol, gently swirl to dissolve, then add 48 mL sterile medium to prepare 20 ug/ml stock solution. Working range: 20-300 ng/ml.

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