T1500

Testosterone

≥98%

• Synonim(y): 17β-Hydroxy-3-oxo-4-androstene, 17β-Hydroxy-4-androsten-3-one, 4-Androsten-17β-ol-3-one, trans-Testosterone
• Wzór empiryczny (zapis Hilla): C₁₉H₂₈O₂
• Numer CAS: 58-22-0
• Masa cząsteczkowa: 288.42
• Beilstein: 1915399
• Numer WE: 200-370-5
• Numer MDL: MFCD00003654
• Kod UNSPSC: 51111800
• Identyfikator substancji w PubChem: 24899970
• NACRES: NA.77

Właściwości

• pochodzenie biologiczne: synthetic (organic)
• Poziom jakości: 200
• sterylność: non-sterile
• Próba: ≥98%
• Postać: powder
• kontrola substancji: USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada
• rozpuszczalność: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 18.2 mg/ml; absolute ethanol: soluble 0.5 mg/ml; chloroform: soluble 100 mg/mL, clear, colorless to very faintly yellow; H₂O: insoluble; dioxane: soluble; methanol: soluble; methyl oleate: slightly soluble; vegetable oils: soluble
• Warunki transportu: ambient
• temp. przechowywania: room temp
• ciąg SMILES: C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O
• InChI: 1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1
• Klucz InChI: MUMGGOZAMZWBJJ-DYKIIFRCSA-N
• informacje o genach: human ... AR(367) , EBP(10682) , ESR1(2099) , PGR(5241) , SERPINA6(866) , SHBG(6462) ; mouse ... Esr1(13982) ; rat ... Ar(24208) , Esr1(24890) , Nr3c1(24413) , Nr3c2(25672) , Pgr(25154)

Opis

Zastosowanie

Testosterone has been used as a standard to study the developmental profile of steroid hormones in male and female rat brains. This hormone has also been used to evaluate its effects on muscle mass and signaling in mice.

Działania biochem./fizjol.

Testosterone secreted by the testis is converted to dihydrotestosterone in the target tissues where it appears to mediate many of the biological actions of testosterone. Androgens direct the development of the male phenotype during embryogenesis and at puberty.

Cechy i korzyści

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Uwaga dotycząca przygotowania

Testosterone dissolves in chloroform at 100 mg/ml to yield a clear, colorless to very faint yellow solution. It is also soluble in methanol, absolute ethanol (0.5 mg/ml), 45 percent (w/v) aqueous 2-hydroxypropyl-b-cyclodextrin (18.2 mg/ml), vegetable oils and dioxane. It is slightly soluble in methyl oleate and insoluble in water.

Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08,GHS07,GHS09
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H302,H351,H360FD,H400
• Zwroty wskazujące środki ostrożności: P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313
• Klasyfikacja zagrożeń: Acute Tox. 4 Oral - Aquatic Acute 1 - Carc. 2 - Repr. 1B
• Kod klasy składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Klasa zagrożenia wodnego (WGK): WGK 3
• Środki ochrony indywidualnej: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges