SRP3073
IL-12 human
recombinant, expressed in CHO cells, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Synonim(y):
CTL maturation factor (TCMF),, Cytotoxic lymphocyte maturation factor (CLMF), NKSF, TSF
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About This Item
Kod UNSPSC:
12352202
NACRES:
NA.32
Polecane produkty
pochodzenie biologiczne
human
rekombinowane
expressed in CHO cells
Próba
≥98% (HPLC)
≥98% (SDS-PAGE)
Postać
lyophilized
siła działania
≤1.0 ng/mL ED50
masa cząsteczkowa
40 kDa
opakowanie
pkg of 10 μg
metody
cell culture | mammalian: suitable
zanieczyszczenia
<0.1 EU/μg endotoxin, tested
kolor
white to off-white
Warunki transportu
wet ice
temp. przechowywania
−20°C
informacje o genach
human ... IL12A(3592)
Opis ogólny
IL-12 (interleukin 12) is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue type mast cells. Recombinant Human IL-12 is a 75kDa heterodimeric glycoprotein consisting of disulfide-linked 35kDa (p35) and 40kDa (p40) subunits (503 total amino acid residues).
Działania biochem./fizjol.
IL-12 (interleukin 12) is a proinflammatory cytokine and plays an important role in protection against pathogens. IL-12 is a potent regulator of cell mediated immune responses and it induces IFN (interferon)-γ production by NK (natural killer) and T cells. Among its biological activities IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-γ producing Th1 (T helper) cells. Polymorphisms in the IL-12 gene are associated with risk of rheumatoid arthritis. It also exhibits anti-tumor activities by enhancing Th1 adaptive immunity and cytotoxic T lymphocyte functions.
Sekwencja
p35 Subunit: RNLPVATPDP GMFPCLHHSQ NLLRAVSNML QKARQTLEFY PCTSEEIDHE DITKDKTSTV EACLPLELTK NESCLNSRET SFITNGSCLA SRKTSFMMAL CLSSIYEDLK MYQVEFKTMN AKLLMDPKRQ IFLDQNMLAV IDELMQALNF NSETVPQKSS LEEPDFYKTK IKLCILLHAF RIRAVTIDRV MSYLNAS p40 Subunit: IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQKE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG DNKEYEYSVE CQEDSACPAA EESLPIEVMV DAVHKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLKNSRQV EVSWEYPDTW STPHSYFSLT FCVQVQGKSK REKKDRVFTD KTSATVICRK NASISVRAQD RYYSSSWSEW ASVPCS
Postać fizyczna
Lyophilized from 0.5x PBS, pH 7.2.
Rekonstytucja
Centrifuge the vial prior to opening. Reconstitute in 1x PBS, pH 7.2-7.4 to a concentration of 0.2 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Klienci oglądali również te produkty
Association between polymorphisms of interleukin 12 and rheumatoid arthritis associated biomarkers in a Chinese population.
Shen L, et al.
Cytokine, 76, 363-367 (2015)
IL-12 induces the production of IFN-gamma by neonatal human CD4 T cells.
Wu CY, et al.
Journal of Immunology, 151, 1938-1949 (1993)
Martin J Page et al.
British journal of haematology, 180(1), 110-117 (2017-11-17)
Inflammation, with its associated inflammatory molecules, is integral to most chronic diseases, including the various cardiovascular diseases. Interleukin 12 (IL12) is one of the inflammatory cytokines that is upregulated during inflammation; however, we know very little about its exact effect
Up-regulation of IL-12 expression in patients with chronic hepatitis B is mediated by the PI3K/Akt pathway.
Wang HW, te al.
Molecular and Cellular Biochemistry, 407, 135-142 (2015)
An absolute and restricted requirement for IL-12 in natural killer cell IFN-gamma production and antiviral defense. Studies of natural killer and T cell responses in contrasting viral infections.
Orange JS and Biron CA
Journal of Immunology, 156, 1138-1142 (1996)
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