SRP2147

CAR-LBD (101-348), GST tagged human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

• Synonim(y): CAR, CAR1, MB67, MGC150433, MGC97144, MGC97209
• Kod UNSPSC: 12352202
• NACRES: NA.26

Właściwości

• pochodzenie biologiczne: human
• rekombinowane: expressed in E. coli
• Próba: ≥70% (SDS-PAGE)
• Postać: frozen liquid
• masa cząsteczkowa: ~55.3 kDa
• opakowanie: pkg of 10 μg
• warunki przechowywania: avoid repeated freeze/thaw cycles
• stężenie: 100 μg/mL
• kolor: clear; colorless
• numer dostępu NCBI: NM_005122
• numer dostępu UniProt: Q14994
• Warunki transportu: dry ice
• temp. przechowywania: −70°C
• informacje o genach: human ... NR1I3(9970)

Opis

Opis ogólny

The gene encoding this protein is localized on human chromosome 1q23.3.

Działania biochem./fizjol.

It forms a complex with phosphatase 2A, heat shock protein 90 (Hsp90) and cytosolic CAR retention protein in the cytoplasm. On activation, it translocates to the nucleus and modulates the expression of genes associated with drug metabolism. The protein regulates transforming growth factor-β (TGF-β) signaling.

The constitutive androstane receptor (CAR) was identified as a member of the orphan nuclear hormone receptor family in 1994. Although constitutively active, it can be further activated by ′phenobarbitol-like′ compounds, the most potent being the synthetic compound TCPOBOP. Upon activation, CAR regulates the xenobiotic drug metabolizing enzymes, cytochrome P450s. There are several overlapping functions between the nuclear receptors PXR and CAR. Recently, CAR, as well as PXR, have been shown to place a role in bile acid clearance and cholestatic liver injury.

Postać fizyczna

Clear and colorless frozen liquid solution

Uwaga dotycząca przygotowania

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable