SRP2066

SRC1 (627-786), biotin, untagged human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

• Synonim(y): F-SRC-1, KAT13A, MGC129719, MGC129720, RIP160, SRC1, bHLHe42, bHLHe74
• NACRES: NA.26
• UNSPSC Code: 12352200
• Assay: ≥80% (SDS-PAGE)
• Biological source: human
• Recombinant: expressed in E. coli

Właściwości

• biological source: human
• recombinant: expressed in E. coli
• assay: ≥80% (SDS-PAGE)
• form: frozen liquid
• mol wt: ~19.8 kDa
• packaging: pkg of 5 μg
• storage condition: avoid repeated freeze/thaw cycles
• color: clear colorless
• NCBI accession no.: NM_003743
• UniProt accession no.: Q15788
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... NCOA1(8648)

Opis

General description

Steroid receptor coactivator 1 (SRC1) is also known as nuclear receptor coactivator 1 (NCOA1). The gene encoding it is localized on human chromosome 2p23.3.

Biochem/physiol Actions

Steroid receptor coactivator 1 (SRC1) is a transcriptional coactivator that mediates the activating functions of many of the nuclear hormone receptors. It is also known as NCoA1 and is a member of the SRC/p160 coactivator family. SRC1 has been shown to be over expressed in some cancers. SRC1 is a 160 kDa protein that contains several LXXLL motifs, which are involved in nuclear receptor interaction. The region 627-786 contains 3 LXXLL motifs that are involved in interaction with nuclear hormone receptorsand has been previously used in assays detecting ligand-dependent receptor-cofactor interactions. This protein does not contain a His tag and will be useful for assays where a native untagged protein is desired. Lane 1 corresponds to 6His-tagged and biotinylated SRC-RID; Lane 2 corresponds to biotinylated SRC-RID without 6His tag.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 10 - Combustible liquids
• Co się dzieje?: WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable