SRP2024

PC4, serine mutations human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

• Synonim(y): MGC102747, P15, PC4, p14
• NACRES: NA.26
• UNSPSC Code: 12352202
• Biological source: human
• Recombinant: expressed in E. coli
• Assay: ≥80% (SDS-PAGE)
• Form: frozen liquid
• Mol wt: ~14.4 kDa

Właściwości

• biological source: human
• recombinant: expressed in E. coli
• assay: ≥80% (SDS-PAGE)
• form: frozen liquid
• mol wt: ~14.4 kDa
• packaging: pkg of 10 μg
• concentration: 1000 μg/mL
• color: clear colorless
• NCBI accession no.: NM_006713
• UniProt accession no.: P53999
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... SUB1(10923)

Opis

Biochem/physiol Actions

Human PC4 is a non-TAF transcription coactivator that mediates activator-dependent transcription by RNA polymerase II in vitro through most tested activators. The function of PC4 is through interactions with transcriptional activators and the basal transcription machinery. It is negatively regulated by casein kinase II phosphorylation both in vitro and in vivo. PC4 strongly binds single stranded DNA and the region essential for the single stranded DNA binding activity was mapped around residue 77. A single amino acid change at position 77 (F to P) abolishes both ds- and ss-DNA binding activity.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 10 - Combustible liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable