SML3960

JNJ-42226314

≥98% (HPLC)

• Synonim(y): [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, [4-[1-[[1-(4-Fluorophenyl)-1H-indol-5-yl]carbonyl]-3-azetidinyl]-1-piperazinyl]-2-thiazolylmethanone
• Wzór empiryczny (zapis Hilla): C₂₆H₂₄FN₅O₂S
• Numer CAS: 1252765-13-1
• Masa cząsteczkowa: 489.56
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD32671350
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C

Opis

Biochem/physiol Actions

Brain penetrant, highly selective and potent reversible inhibitor of monoacylglycerol lipase (MAGL).


JNJ-42226314 is a brain penetrant, highly selective and potent reversible inhibitor of monoacylglycerol lipase (MAGL)(IC50 = 1.1) that exhibits antinociceptive efficacy in the rat models neuropathic and inflammatory pain. JNJ-42226314 elevates hippocampal 2-arachidonoylglycerol (2-AG) levels and prolongs wakefulness in rats.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable