SML3711

DENSPM tetrahydrochloride

≥98% (HPLC)

• Synonim(y): BE 333 HCl, BENSpm HCl, DENSpm 4HCl, N1,N11-Diethylnorspermine tetrahydrochloride, N1,N11-bis(ethyl)norspermine tetrahydrochloride
• Wzór empiryczny (zapis Hilla): C₁₃H₃₂N₄· 4HCl
• Numer CAS: 156886-85-0
• Masa cząsteczkowa: 390.26
• UNSPSC Code: 41121800
• NACRES: NA.21
• MDL number: MFCD00871200
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Opis

Biochem/physiol Actions

DENSPM HCl is a nontoxic polyamine analog that enhances polyamine catabolism and production of hazardous hydrogen peroxide and N-acetyl-3-aminopropanal by inducing spermidine/spermine-N1-acetyl transferase (SSAT) expression. DENSPM HCl improves stem cell maintenance through reduced translation, exhibits slower proliferation rates in cancer cells, and induces autophagy. It shows greater antitumor activity and less associated toxicity in a human melanoma xenograft model.

Polyamine pathway inhibitor; potent inducer of spermidine/spermine N1-acetyltransferase

Disclaimer

Hygroscopic

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable