SML3088

MRK-016

≥98% (HPLC)

• Synonim(y): 3-(1,1-Dimethylethyl)-7-(5-methyl-3-isoxazolyl)-2-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-pyrazolo[1,5-d][1,2,4]triazine, 3-tert-Butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d][1,2,4]triazine, MRK 016, MRK016
• Wzór empiryczny (zapis Hilla): C₁₇H₂₀N₈O₂
• Numer CAS: 342652-67-9
• Masa cząsteczkowa: 368.39
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD18086893
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CC(C)(C1=C2C=NN=C(N2N=C1OCC3=NC=NN3C)C4=NOC(C)=C4)C
• InChI: 1S/C17H20N8O2/c1-10-6-11(23-27-10)15-21-19-7-12-14(17(2,3)4)16(22-25(12)15)26-8-13-18-9-20-24(13)5/h6-7,9H,8H2,1-5H3
• InChI key: QYSYOGCIDRANAR-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

MRK-016 is an orally active, benzodiazepine site-targeting, alpha5-selective GABAA inverse agonist (Emax = -55%/α5, -16%/α1, -9%/α3, +6%/α2 of a EC20 GABA response using respective recombinant human αβ3γ2) with in vivo cognition-enhancing properties (0.3-3 mg/kg p.o. in rat Morris water maze test).

Orally active, benzodiazepine site-targeting, alpha5 (α5) subtype-selective GABAA inverse agonist with cognition-enhancing properties in vivo.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable