SML3006

ICCB-19 Hydrochloride

≥98% (HPLC)

• Synonim(y): N-Cycloheptyl-2-[(4,5-dihydro-1H-imidazol-2-yl)thio]acetamide hydrochloride
• Wzór empiryczny (zapis Hilla): C₁₂H₂₁N₃OS · HCl
• Numer CAS: 1803605-68-6
• Masa cząsteczkowa: 291.84
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD28145281
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(NC1CCCCCC1)CSC2=NCCN2.Cl
• InChI key: TZICOTBZKPHMMK-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

ICCB-19 is a cell penetrant apoptosis inhibitor that activates autophagy leading to restoration of cellular homeostasis in cells with accumulated mutant tau, α-synuclein, or huntingtin. ICCB-19 potently and selectively inhibits TRADD. It binds to the N-terminal TRAF2-binding domain of TRADD (TRADD-N). Apparently ICCB-19 releases cIAP1/2 or TRAF2 from TRADD thus promoting the K63-linked ubiquitination of beclin 1.

cell penetrant apoptosis inhibitor that activates autophagy that potently and selectively inhibits TRADD

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable