SML2615

Ixabepilone

≥98% (HPLC)

• Synonim(y): (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione, Azaepothilone B, BMS-247550, NSC-710428
• Wzór empiryczny (zapis Hilla): C₂₇H₄₂N₂O₅S
• Numer CAS: 219989-84-1
• Masa cząsteczkowa: 506.70
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD04307791
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: protect from light

Właściwości

• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D -35 to -45°, c = 1.0 in chloroform-d
• storage condition: protect from light
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: [s]1c(nc(c1)\C=C(\[C@H]2NC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]([C@H](CCC[C@]3(O[C@H]3C2)C)C)O)C)(C)C)O)/C)C
• InChI: 1S/C27H42N2O5S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)29-23(31)13-21(30)26(5,6)25(33)17(3)24(15)32/h11,14-15,17,20-22,24,30,32H,8-10,12-13H2,1-7H3,(H,29,31)/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1
• InChI key: FABUFPQFXZVHFB-PVYNADRNSA-N

Opis

Biochem/physiol Actions

Ixabepilone is a microtubule stabilizing semisynthetic lactam analog of epothilone B. It appears that Ixabepilone is unaffected by BCRP mediated chemoresistance.

Microtubule stabilizing agent that is unaffected by BCRP mediated chemoresistance

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H301,H341,H361fd,H372
• pcodes: P202 - P260 - P264 - P280 - P301 + P310 - P405
• Hazard Classifications: Acute Tox. 3 Oral - Muta. 2 - Repr. 2 - STOT RE 1
• target_organs: Gastro-intestinal system,hematopoietic system,Nervous system,lymphatics
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable