CW3388 is a cell active and highly potent enhancer of oligodendrocyte formation. CW3388 potently inhibits the cholesterol biosynthesis enzyme Δ8,7-sterol isomerase (EBP). It promotes myelination in vitro.
cell active and highly potent enhancer of oligodendrocyte formation; inhibitor of Δ8,7-sterol isomerase (EBP)
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Cell chemical biology, 26(4), 593-599 (2019-02-19)
Small molecules that promote oligodendrocyte formation have been identified in "drug repurposing" screens to nominate candidate therapeutics for diseases in which myelin is lost, including multiple sclerosis. We recently reported that many such molecules enhance oligodendrocyte formation not by their
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