SML2525

Tafluprost

≥98% (HPLC)

• Synonim(y): (5Z)-7-[(1R,2R,3R,5S)-2-[(1E)-3,3-Difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-5-heptenoic acid 1-methylethyl ester, 16-phenoxy-15-deoxy-15,15-difluoro-17,18,19,20-tetranorprostaglandin F2α isopropyl ester, AFP-168
• Wzór empiryczny (zapis Hilla): C₂₅H₃₄F₂O₅
• Numer CAS: 209860-87-7
• Masa cząsteczkowa: 452.53
• UNSPSC Code: 51111800
• NACRES: NA.77
• MDL number: MFCD08062150
• Assay: ≥98% (HPLC)
• Form: oil

Właściwości

• assay: ≥98% (HPLC)
• form: oil
• optical activity: [α]/D +20 to +25°, c = 1 in chloroform-d
• color: colorless to yellow
• storage temp.: −20°C
• SMILES string: FC(F)(COc2ccccc2)\C=C\C1C(CC(C1C\C=C\CCCC(=O)OC(C)C)O)O
• InChI: 1S/C25H34F2O5/c1-18(2)32-24(30)13-9-4-3-8-12-20-21(23(29)16-22(20)28)14-15-25(26,27)17-31-19-10-6-5-7-11-19/h3,5-8,10-11,14-15,18,20-23,28-29H,4,9,12-13,16-17H2,1-2H3/b8-3+,15-14+
• InChI key: WSNODXPBBALQOF-ZHDUIJGQSA-N

Opis

Biochem/physiol Actions

Prostaglandin F2α agonist; Antiglaucoma agent

Taflupost is a prostaglandin F2α agonist that lowers intraocular pressure and is used in the treatment of glaucoma. It has high affinity and selectivity for the fluoroprostaglandin (FP) receptor PGF2α. Tafluprost is believed to reduce the intraocular pressure (IOP) by increasing the outflow of aqueous humor. Tafluprost is a pro-drug. The active metabolite is the free acid.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS08
• signalword: Warning
• hcodes: H361d
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable