SML2385

Andrastin A

≥95% (HPLC)

• Synonim(y): (3β,5β,8α,9β,10α,13α)-3β-(acetyloxy)-4,4,8,12,16-pentamethyl-15,17,19-trioxoandrost-11-ene-14-carboxylic acid methyl ester
• Wzór empiryczny (zapis Hilla): C₂₈H₃₈O₇
• Numer CAS: 174232-42-9
• Masa cząsteczkowa: 486.60
• UNSPSC Code: 12352200
• MDL number: MFCD28898503
• NACRES: NA.21
• Assay: ≥95% (HPLC)
• Form: powder

Właściwości

• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• storage temp.: −20°C
• SMILES string: O(C1C(C2[C@@]([C@@H]3C(C4([C@](C(=C3)C)(C(=O)C(C4=O)C)C)C(=O)OC)(CC2)C)(CC1)C=O)(C)C)C(=O)C
• InChI: 1S/C28H38O7/c1-15-13-19-25(6,28(23(33)34-8)22(32)16(2)21(31)26(15,28)7)11-9-18-24(4,5)20(35-17(3)30)10-12-27(18,19)14-29/h13-14,16,18-20H,9-12H2,1-8H3/t16?,18?,19-,20?,25?,26+,27+,28?/m0/s1
• InChI key: GRBXNADBNJGZRK-BCMOVVIDSA-N

Opis

Biochem/physiol Actions

Andrastin A is a meroterpenoid protein farnesyltransferase inhibitor with anticancer activity. It has been shown to inhibit the farnesyltransferase activity of the oncogenic Ras proteins and inhibit the efflux of anticancer drugs from multidrug-resistant cancer cells.

Farnesyltransferase inhibitor with anticancer activity; mycotoxin

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable