Izosilybina to diastereoizomeryczna mieszanina flawonolignanów izosilybiny A i izosilybiny B wyizolowana z ostropestu plamistego (Silybum marianum), która wykazuje działanie hepatoprotekcyjne. Izosilibina silnie hamuje aktywność cytochromu P4502C8 (CYP2C8) w ludzkich mikrosomach wątroby. Isosilybin jest również aktywatorem PPARγ.
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Journal of natural products, 77(4), 842-847 (2014-03-07)
Peroxisome proliferator-activated receptor gamma (PPARγ) is a key regulator of glucose and lipid metabolism. Agonists of this nuclear receptor are used in the treatment of type 2 diabetes and are also studied as a potential treatment of other metabolic diseases
Milk thistle is a widely-consumed botanical used for an array of purported health benefits. The primary extract of milk thistle is termed silymarin, a complex mixture that contains a number of structurally-related flavonolignans, the flavonoid, taxifolin, and a number of
Journal of natural products, 66(9), 1171-1174 (2003-09-27)
Two pairs of diastereoisomeric flavonolignans, silybin A, silybin B, isosilybin A, and isosilybin B, were successfully separated from Silybum marianum by sequential silica gel column chromatography, preparative reversed-phase HPLC, and recrystallization. Complete stereochemical assignments at C-2, C-3, C-7', and C-8'
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