SML2361

Kinesore

>97% (HPLC)

• Synonim(y): 3,5-Dibromo-4-hydroxy-benzoic acid 2-[[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]methylene]hydrazide, 3,5-Dibromo-N′-{[2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl]methylene}-4-hydroxybenzohydrazide
• Wzór empiryczny (zapis Hilla): C₂₀H₁₆Br₂N₄O₄
• Numer CAS: 363571-83-9
• Masa cząsteczkowa: 536.17
• UNSPSC Code: 31401503
• NACRES: NA.77
• MDL number: MFCD02636553
• Assay: >97% (HPLC)
• Form: powder

Właściwości

• assay: >97% (HPLC)
• form: powder
• color: white to brown
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: Brc1c(c(cc(c1)C(=O)N\N=C\c2c([n](c(c2)C)c3cc(ccc3)[N+](=O)[O-])C)Br)O
• InChI: 1S/C20H16Br2N4O4/c1-11-6-14(12(2)25(11)15-4-3-5-16(9-15)26(29)30)10-23-24-20(28)13-7-17(21)19(27)18(22)8-13/h3-10,27H,1-2H3,(H,24,28)/b23-10+
• InChI key: DUGCMEGLYHBMAR-AUEPDCJTSA-N

Opis

Biochem/physiol Actions

Kinesore is a cell penetrant and potent activator of kinesin-1 that induces kinesin light chain tetratricopeptide repeat domain-dependent kinesin-1 activation in the absence of organelle cargo-adaptor engagement. It inhibits kinesin-1 interaction with peptide fragment of organelle-specific cargo adaptors. Kinesore induces kinesin light chain conformational switch that causes remodeling of the microtubule network in cells.

cell penetrant and potent activator of kinesin-1 that causes remodeling of the microtubule network in cells

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable