SML1890

MK204

≥98% (HPLC)

• Synonim(y): 2-[5-Chloro-2-[[[(2,3,4,5,6-pentabromophenyl)methyl]amino]carbonyl]phenoxy]-acetic acid
• Wzór empiryczny (zapis Hilla): C₁₆H₉Br₅ClNO₄
• Numer CAS: 1959605-73-2
• Masa cząsteczkowa: 714.22
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 3 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: O=C(C1=C(OCC(O)=O)C=C(C=C1)Cl)NCC(C(Br)=C(C(Br)=C2Br)Br)=C2Br
• InChI: 1S/C16H9Br5ClNO4/c17-11-8(12(18)14(20)15(21)13(11)19)4-23-16(26)7-2-1-6(22)3-9(7)27-5-10(24)25/h1-3H,4-5H2,(H,23,26)(H,24,25)
• InChI key: QYSFXUVFRUYJCZ-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

MK204 is a potent and selective inhibitor of aldo-keto reductase family member 1B10 (AKR1B10).

MK204 is a potent and selective inhibitor of aldo-keto reductase family member 1B10 (AKR1B10). AKR1B10 is induced in several cancer types, in particular, hepatocellular carcinoma, and may be involved with drug resistance. MK204 appears to target a distinct AKR1B10 inner specificity pocket not present in the closely related aldose reductase. MK204 had an IC₅₀ value of 80 nM compared to an IC₅₀ value of 21.7 μM for aldose reductase.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable