SML1601

NSC59984

≥98% (HPLC)

• Synonim(y): (E)-1-(4-Methylpiperazin-1-yl)-3-(5-nitrofuran-2yl)prop-2-en-1-one, 1-(4-Methyl-1-piperazinyl)-3-(5-nitro-2-furanyl)-2-propen-1-one, 1-Methyl-4-[3-(5-nitro-2-furanyl)-1-oxo-2-propenyl]-piperazine, CID 5356520, MLS000737358
• Wzór empiryczny (zapis Hilla): C₁₂H₁₅N₃O₄
• Numer CAS: 803647-40-7
• Masa cząsteczkowa: 265.27
• NACRES: NA.77
• PubChem Substance ID: 329825487
• UNSPSC Code: 12352200
• MDL number: MFCD29905462
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: yellow to brown
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: CN1CCN(C(/C=C/C2=CC=C([N+]([O-])=O)O2)=O)CC1
• InChI: 1S/C12H15N3O4/c1-13-6-8-14(9-7-13)11(16)4-2-10-3-5-12(19-10)15(17)18/h2-5H,6-9H2,1H3/b4-2+
• InChI key: QKTRIGNWBRHBFV-DUXPYHPUSA-N

Opis

Biochem/physiol Actions

NSC59984 targets various mutant p53 to restore wild-type p53 pathway via the activation of p73 in cancer cells.

NSC59984 targets various mutant p53 to restore wild-type p53 pathway via the activation of p73 in cancer cells. NSC59984 depletes a gain of function (GOF p53 mutants. NSC59984 is not cytotoxic against normal cells.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable