SML1242

SGC707

≥98% (HPLC)

• Synonim(y): 1-Isoquinolin-6-yl-3-(2-oxo-2-pyrrolidin-1-yl-ethyl)-urea
• Wzór empiryczny (zapis Hilla): C₁₆H₁₈N₄O₂
• Numer CAS: 1687736-54-4
• Masa cząsteczkowa: 298.34
• Kod UNSPSC: 51111800
• Identyfikator substancji w PubChem: 329825739
• NACRES: NA.77

Właściwości

• Poziom jakości: 100
• Próba: ≥98% (HPLC)
• Postać: powder
• kolor: white to light brown
• rozpuszczalność: DMSO: 20 mg/mL, clear
• temp. przechowywania: 2-8°C
• ciąg SMILES: O=C(NCC(N1CCCC1)=O)NC2=CC3=CC=NC=C3C=C2
• InChI: 1S/C16H18N4O2/c21-15(20-7-1-2-8-20)11-18-16(22)19-14-4-3-13-10-17-6-5-12(13)9-14/h3-6,9-10H,1-2,7-8,11H2,(H2,18,19,22)
• Klucz InChI: DMIDPTCQPIJYFE-UHFFFAOYSA-N

Opis

Działania biochem./fizjol.

SGC707 is a potent allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). SGC707 has an IC₅₀ value of 50 nM and >100-fold selectivity over other methyltransferases and non-epigenetic targets. SGC707 binds to PRMT3 with KD of 50 nM (ITC), and inhibits histone methylation in cells with an IC₅₀ value below 1 μM. For full characterization details, please visit the SGC707 probe summary on the Structural Genomics Consortium (SGC) website.

XY1 is the negative control for the active probe, SGC707. To request a sample of the negative control from the SGC, click here.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

Cechy i korzyści

SGC707 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Inne uwagi

SGC707 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the SGC707 probe summary on the Chemical Probes Portal website.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS05
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H318
• Zwroty wskazujące środki ostrożności: P280 - P305 + P351 + P338
• Klasyfikacja zagrożeń: Eye Dam. 1
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable