SML1234

HAMNO

≥98% (HPLC)

• Synonim(y): (1Z)-1-[(2-Hydroxyanilino)methylidene]naphthalen-2-one, 1-[[(2-Hydroxyphenyl)imino]methyl]-2-naphthalenol, CID 6335338, MLS000737724, NS C111847, NSC111847
• Wzór empiryczny (zapis Hilla): C₁₇H₁₃NO₂
• Numer CAS: 138736-73-9
• Masa cząsteczkowa: 263.29
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: yellow to orange
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: N(c3c(cccc3)O)\C=C1\c2c(cccc2)C=CC\1=O
• InChI key: NADCEWZYITXLKJ-KAMYIIQDSA-N

Opis

Biochem/physiol Actions

HAMNO is a potent and selective inhibitor of replication protein A (RPA) interactions with proteins involved in the replication stress response. HAMNO binds the N-terminal domain of RPA70 and inhibits both ATR autophosphorylation and phosphorylation of RPA32 Ser33 by ATR. HAMNO enhances DNA replication stress in cancer cells and slow tumor growth in vivo.

HAMNO is a potent and selective inhibitor of replication protein A (RPA) interactions.

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable