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SML1154
Clostridium difficile Toxin A
≥95% (SDS-PAGE), lyophilized powder, cellular toxin
Synonim(y):
TcdA
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| Do Państwa/SKU | Dostępność | Cena netto |
|---|---|---|
2 μg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 1940,00 zł |
50 μg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 2870,00 zł |
Informacje o tej pozycji
Assay:
≥95% (SDS-PAGE)
Form:
lyophilized powder
1940,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
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Pozwól nam pomócNazwa produktu
Clostridium difficile Toxin A, ≥95% (SDS-PAGE)
Quality Segment
assay
≥95% (SDS-PAGE)
form
lyophilized powder
storage temp.
2-8°C
General description
Native toxin A purified from C. difficile strain VPI10463 (toxinotype 0)
Biochem/physiol Actions
Clostridium difficile Toxin A and B, cation-dependent UDP-glucose glucosyltransferases, are cellular toxins that inactivate Rho (and Rho family small GTPases) through monoglucosylation of these family members. TcdA elicits effects primarily within the intestinal epithelium. Effects of this monoglucosylation include disregulation of the actin cytoskeleton, cell rounding, cytotoxicity, and altered cellular signaling. Rho proteins are monoglucosylated by Toxin A and B using UDP-glucose as a cosubstrate. Rho, Rac and Cdc42 are included in the Rho subfamilies targeted by both toxins. Low molecular mass GTP-binding proteins that are not modified by Toxin A and B include Ras, Rab, Arf, or Ran subfamilies as well as heterotrimeric G proteins.
TcdA is a cellular toxin that inactivates Rho (and Rho family small GTPases) through monoglucosylation of these family members. TcdA elicits effects primarily within the intestinal epithelium.
Preparation Note
Contents of the 50UG sku when reconstituted in 250 μL sterile distilled water will contain Toxin A at a concentration of approximately 0.2 mg/mL in 0.05M Hepes, 0.15M sodium chloride and 5% sucrose.
Contents of the 2UG sku when reconstituted in 250 μL sterile distilled water will contain Toxin A at a concentration of approximately 8 μg/mL in 0.05M Hepes, 0.15M sodium chloride and 5% sucrose.
Contents of the 2UG sku when reconstituted in 250 μL sterile distilled water will contain Toxin A at a concentration of approximately 8 μg/mL in 0.05M Hepes, 0.15M sodium chloride and 5% sucrose.
Other Notes
After reconstitution, the reconstituted liquid can be frozen at -80 °C to -20 °C to extend stability to 1 year; however every freeze/thaw cycle wil cause increased aggregation. Avoid multiple freeze/thaw cycles and multiple temperature fluctuations.
Mixing: Swirl or pipette gently to mix. Vortexing may promote aggregation.
Mixing: Swirl or pipette gently to mix. Vortexing may promote aggregation.
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Ta pozycja | |||
|---|---|---|---|
| assay ≥95% (SDS-PAGE) | assay ≥95% (SDS-PAGE) | assay ≥90% (SDS-PAGE) | assay ≥95% (SDS-PAGE) |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form lyophilized powder |
| Quality Level 200 | Quality Level 200 | Quality Level 300 | Quality Level 200 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C |
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation
Klasa składowania
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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