SML0603

Lixivaptan

≥96% (HPLC)

• Synonim(y): N-[3-Chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepine-10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-methylbenzamide, VPA 985, WAY-VPA 985
• Wzór empiryczny (zapis Hilla): C₂₇H₂₁ClFN₃O₂
• Numer CAS: 168079-32-1
• Masa cząsteczkowa: 473.93
• UNSPSC Code: 51111800
• NACRES: NA.77
• Assay: ≥96% (HPLC)
• Form: powder

Właściwości

• description: 4% w/w in ethyl acetate
• Quality Segment: 100
• assay: ≥96% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: room temp
• SMILES string: Fc1cc(c(cc1)C)C(=O)Nc2cc(c(cc2)C(=O)N3Cc4[n](ccc4)Cc5c3cccc5)Cl
• InChI: 1S/C27H21ClFN3O2/c1-17-8-9-19(29)13-23(17)26(33)30-20-10-11-22(24(28)14-20)27(34)32-16-21-6-4-12-31(21)15-18-5-2-3-7-25(18)32/h2-14H,15-16H2,1H3,(H,30,33)
• InChI key: PPHTXRNHTVLQED-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

Arginine vasopressin (AVP) plays an important part in circulatory and water homoeostasis and is important in renal hemodynamic alterations, water retention, and cardiac remodeling in congestive heart failure (CHF). Lixivaptan is an AVP V2-receptor selective antagonist that increases water excretion and normalizes serum sodium levels. Lixivaptan has been in clinical trials for hyponatremia associated with heart failure.

Lixivaptan is an arginine vasopressin (AVP) V2-receptor antagonist.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable