SML0494

VU0361737

≥98% (HPLC)

• Synonim(y): CID-44191096, ML128, N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide
• Wzór empiryczny (zapis Hilla): C₁₃H₁₁ClN₂O₂
• Numer CAS: 1161205-04-4
• Masa cząsteczkowa: 262.69
• NACRES: NA.77
• PubChem Substance ID: 329825444
• UNSPSC Code: 12352200
• MDL number: MFCD16618402
• Assay: ≥98% (HPLC)
• Form: film

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: film
• color: white
• solubility: DMSO: 15 mg/mL (clear solution)
• storage temp.: 2-8°C
• SMILES string: COc1cc(NC(=O)c2ccccn2)ccc1Cl
• InChI: 1S/C13H11ClN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)
• InChI key: ARYUXFNGXHNNDM-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

VU0361737 is an mGluR4-specific positive allosteric modulator (PAM) with greater than 50 fold selectivity over other mGluR subtypes. The EC₅₀ values for human and rat mGlu4 are 240 and 110 nM, respectively, compared to greater than 10 mM for all other mGluRs.

VU0361737 is an mGluR4-specific positive allosteric modulator (PAM).

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H319
• pcodes: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable