SML0481

Qc1

≥98% (HPLC)

• Synonim(y): 1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide
• Wzór empiryczny (zapis Hilla): C₂₃H₁₆F₃N₃O₂S
• Numer CAS: 403718-45-6
• Masa cząsteczkowa: 455.45
• NACRES: NA.77
• PubChem Substance ID: 329825432
• UNSPSC Code: 12352200
• MDL number: MFCD02649259
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL (clear solution, warmed)
• storage temp.: 2-8°C
• SMILES string: FC(F)(F)c1cccc(c1)N2C(=S)Nc3cc(ccc3C2=O)C(=O)NCc4ccccc4
• InChI: 1S/C23H16F3N3O2S/c24-23(25,26)16-7-4-8-17(12-16)29-21(31)18-10-9-15(11-19(18)28-22(29)32)20(30)27-13-14-5-2-1-3-6-14/h1-12H,13H2,(H,27,30)(H,28,32)
• InChI key: IFNVTSPDMUUAFY-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

Qc1 is a reversible inhibitor of threonine dehydroxygenase (TDH).

Qc1 is a reversible inhibitor of threonine dehydroxygenase (TDH). The IC₅₀ value for inhibition of TDH by Qc1 is 500 nM, with no detectable inhibition of other dehydroxygenase enzymes at concentrations up to 10 mM. Qc1 induces arrest and autophagy of mouse ES cells with an EC₅₀ of 3 mM.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable