SML0468

Dorzolamide

≥98% (HPLC)

• Synonim(y): (4S,6S)-4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, 4S,6S-Dorzolamide, L-671,152, MK-507
• Wzór empiryczny (zapis Hilla): C₁₀H₁₆N₂O₄S₃
• Numer CAS: 120279-96-1
• Masa cząsteczkowa: 324.44
• NACRES: NA.77
• PubChem Substance ID: 329824746
• UNSPSC Code: 12352200
• MDL number: MFCD00865636
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D -25 to -35°, c = 1 in methanol
• color: white to beige
• solubility: DMSO: 5 mg/mL (clear solution, warmed)
• storage temp.: room temp
• SMILES string: CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O
• InChI: 1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1
• InChI key: IAVUPMFITXYVAF-XPUUQOCRSA-N
• Gene Information: human ... CA2(760)

Opis

Biochem/physiol Actions

Dorzolamide is a potent carbonic anhydrase II inhibitor with an IC₅₀ value of 0.16 nM on human erythrocyte carbonic anhydrase II in vitro. It has been found to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.

Dorzolamide is a potent carbonic anhydrase II inhibitor.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable