SML0420

TAPI-2 acetate salt

≥98% (HPLC), matrix metalloproteinases and TACE inhibitor, lyophilized powder

• Synonim(y): N-(R)-(2-(Hydroxyaminocarbonyl)methyl)-4-methylpentanoyl-L-t-butyl-glycine-L-alanine 2-aminoethyl amide, Tumor necrosis factor-α protease inhibitor-2, TNF-α protease inhibitor-2
• Wzór empiryczny (zapis Hilla): C₁₉H₃₇N₅O₅ · xC₂H₄O₂
• Numer CAS: 689284-12-6
• Masa cząsteczkowa: 415.53 (free base basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825415
• NACRES: NA.77
• MDL number: MFCD22666396
• Assay: ≥98% (HPLC)
• Form: lyophilized powder

Właściwości

• Nazwa produktu: TAPI-2 acetate salt, ≥98% (HPLC)
• assay: ≥98% (HPLC)
• form: lyophilized powder
• color: white to off-white
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: CC(O)=O.CC(C)C[C@H](CC(=O)NO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)NCCN)C(C)(C)C
• InChI: 1S/C19H37N5O5.C2H4O2/c1-11(2)9-13(10-14(25)24-29)17(27)23-15(19(4,5)6)18(28)22-12(3)16(26)21-8-7-20;1-2(3)4/h11-13,15,29H,7-10,20H2,1-6H3,(H,21,26)(H,22,28)(H,23,27)(H,24,25);1H3,(H,3,4)/t12-,13+,15+;/m0./s1
• InChI key: LMUSZKBIFGOFBD-RAFLFFCLSA-N

Opis

Application

TAPI-2 acetate salt has been used to inhibit protease activity in HepG2 cells.

Biochem/physiol Actions

TAPI-2 is a potent inhibitor matrix metalloproteinases and TACE (TNF-α convertase/ADAM17/α-secretase).

TAPI-2 is a potent inhibitor matrix metalloproteinases and TACE (TNF-α convertase/ADAM17/α-secretase). It blocks the shedding of several cell surface proteins such as β-amyloid precursor protein, inhibits TNF-α release as well as a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands. TAPI-2 is considered a fairly broad metalloproteinase inhibitor, but it much more selective for TACE than GM6001.

Features and Benefits

This compound is featured on the Cytokine Receptors (Tumor Necrosis Receptor Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable