SML0314

CGP77675

≥98% (HPLC)

• Synonim(y): 1-(2-{4-[4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]phenyl}ethyl)piperidin-4-ol, 1-(4-(4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenethyl)piperidin-4-ol, CGP 77675, CGP-77675
• Wzór empiryczny (zapis Hilla): C₂₆H₂₉N₅O₂
• Numer CAS: 234772-64-6
• Masa cząsteczkowa: 443.54
• Numer MDL: MFCD20039929
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 329825319
• NACRES: NA.77

Właściwości

• Próba: ≥98% (HPLC)
• Formularz: powder
• kolor: white to beige
• rozpuszczalność: DMSO: >10 mg/mL
• temp. przechowywania: 2-8°C
• ciąg SMILES: COc1cccc(c1)-c2cn(-c3ccc(CCN4CCC(O)CC4)cc3)c5ncnc(N)c25
• InChI: 1S/C26H29N5O2/c1-33-22-4-2-3-19(15-22)23-16-31(26-24(23)25(27)28-17-29-26)20-7-5-18(6-8-20)9-12-30-13-10-21(32)11-14-30/h2-8,15-17,21,32H,9-14H2,1H3,(H2,27,28,29)
• Klucz InChI: WUPXZZWTHIZICK-UHFFFAOYSA-N

Opis

Opis ogólny

CGP77675 belongs to the pyrrolopyrimidine class of inhibitors.[1]

Zastosowanie

CGP77675 has been used in the generation of mouse expanded potential stem cells.[2]

Działania biochem./fizjol.

CGP77675 is a potent Src kinase inhibitor.

CGP77675 is a potent Src kinase inhibitor. CGP77675 is selective toward other protein kinases including Cdc2 (>500-fold), epidermal growth factor (EGF) receptor (7.5-fold), vascular endothelial growth factor receptor (>50-fold), and for v-Abl (15-fold) and focal adhesion kinase (Fak) (>25-fold).

CGP77675 prevents hypercalcemia stimulated by interleukin 1β. It is known to offer protection against bone loss in ovariectomized mice.[1] CGP77675 is known for its use in cancer treatment.[3]

Cechy i korzyści

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable