SML0213

MC2050 hydrate

≥98% (HPLC)

• Synonim(y): 2-[2-(4-(2-pyridyl)-1-piperazinyl)ethylsulfanyl]-3H-quinazolin-4-one dihydrochloride hydrate
• Wzór empiryczny (zapis Hilla): C₁₉H₂₁N₅OS·2HCl · xH₂O
• Masa cząsteczkowa: 440.39 (anhydrous basis)
• NACRES: NA.77
• PubChem Substance ID: 329825234
• UNSPSC Code: 12352200
• MDL number: MFCD21608523
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: H₂O: ≥5 mg/mL at warmed to 60 °C
• storage temp.: 2-8°C
• SMILES string: O.Cl.Cl.O=C1NC(SCCN2CCN(CC2)c3ccccn3)=Nc4ccccc14
• InChI: 1S/C19H21N5OS.2ClH.H2O/c25-18-15-5-1-2-6-16(15)21-19(22-18)26-14-13-23-9-11-24(12-10-23)17-7-3-4-8-20-17;;;/h1-8H,9-14H2,(H,21,22,25);2*1H;1H2
• InChI key: LMZZPRHHBPFDGE-UHFFFAOYSA-N

Opis

Application

MC2050 hydrate may be used in cell signaling studies.

Biochem/physiol Actions

MC2050 is a PARP-1 inhibitor

MC2050 is a water-soluble PARP-1 inhibitor. The IC₅₀ for inhibition of PARP-1 activity is 119 nM, compared to 1.8 μM for PARP-2. MC2050 inhibits apoptosis and blocks poly ADP-ribosylation of histone H1 in hydrogen peroxide treated SH-SY5Y neuroblastoma cells.

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable