SMB01024

Diuvaretin

≥90% (LC/MS-ELSD)

• Synonim(y): 1-[2,4-dihydroxy-3,5-bis[(2-hydroxyphenyl)methyl]-6-methoxyphenyl]-3-phenylpropan-1-one
• Wzór empiryczny (zapis Hilla): C₃₀H₂₈O₆
• Numer CAS: 61463-04-5
• Masa cząsteczkowa: 484.54
• UNSPSC Code: 12352205
• NACRES: NA.25
• MDL number: MFCD18975655

Właściwości

• biological source: plant
• assay: ≥90% (LC/MS-ELSD)
• form: solid
• mol wt: 484.54
• solubility: water: slightly soluble
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: −20°C
• SMILES string: O(C)c1c(c(c(c(c1C(=O)CCc4ccccc4)O)Cc3c(cccc3)O)O)Cc2c(cccc2)O
• InChI: 1S/C30H28O6/c1-36-30-23(18-21-12-6-8-14-25(21)32)28(34)22(17-20-11-5-7-13-24(20)31)29(35)27(30)26(33)16-15-19-9-3-2-4-10-19/h2-14,31-32,34-35H,15-18H2,1H3
• InChI key: KDEMELRYKGOXDL-UHFFFAOYSA-N

Opis

General description

Diuvaretin, a dihydrochalcone, is a natural product commonly available from Dipteryx odorata, Uvaria acuminata and Uvaria chamae plants. This plant metabolite exhibits various biological activities such as anti-inflammatory, antioxidant, antineoplastic, anti-angiogenic, and antimalarial properties.

Application

It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Biochem/physiol Actions

Diuvaretin exhibits cytotoxicity towards human promyelocytic leukemia HL-60 cells. It has a role as a metabolite, an antineoplastic agent and an antimalarial.

Diuvaretin inhibits NF-kB activation, hindering inflammation and cancer. It also suppresses tumor cell proliferation, induces apoptosis, and diminishes tumor growth and angiogenesis in mouse cancer models.

Features and Benefits

• High quality compound suitable for multiple research applications
• Compatible with HPLC and mass spectrometry techniques

Other Notes

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable