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SAE0066
Adenylyl Cyclase Toxin from Bordetella pertussis
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| Do Państwa/SKU | Dostępność | Cena netto |
|---|---|---|
50 μg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 2650,00 zł |
Informacje o tej pozycji
NACRES:
NA.26
UNSPSC Code:
12352200
Specific activity:
≥ 50 units/mg protein
Assay:
≥70%
Biological source:
Bordetella pertussis Tohama I
2650,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
Pomoc techniczna
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Pozwól nam pomócbiological source
Bordetella pertussis Tohama I
Quality Segment
assay
≥70%
form
liquid
specific activity
≥ 50 units/mg protein
technique(s)
cell culture | mammalian: suitable
suitability
suitable for molecular biology
application(s)
detection
storage temp.
−20°C
Gene Information
Bordetella pertussis Tohama I ... CyaA(69600712)
General description
Research area: IMMUNO AND CKS
Adenylate Cyclase Toxin (ACT or CyaA) is a member of the extensive family of toxins known as Repeat in Toxin (RTX), which are produced by Gram-negative organisms. ACT is encoded by the cyaA gene and secreted extracellularly in the form of a soluble protein. It exhibits both adenylate cyclase enzymatic activity and hemolytic activity. The synthesis, maturation, and secretion of ACT are regulated by the CyaCABD operon. Moreover, its specific cellular receptor, CD11b/CD18 integrin (αMβ2, Mac-1, or CR3), is expressed on myeloid phagocytes.
Adenylate Cyclase Toxin (ACT or CyaA) is a member of the extensive family of toxins known as Repeat in Toxin (RTX), which are produced by Gram-negative organisms. ACT is encoded by the cyaA gene and secreted extracellularly in the form of a soluble protein. It exhibits both adenylate cyclase enzymatic activity and hemolytic activity. The synthesis, maturation, and secretion of ACT are regulated by the CyaCABD operon. Moreover, its specific cellular receptor, CD11b/CD18 integrin (αMβ2, Mac-1, or CR3), is expressed on myeloid phagocytes.
Application
Adenylyl Cyclase Toxin from Bordetella pertussis has been used as Gα(i/o) inhibitor to study the involvement of the sphingosine 1-phosphate receptor 2/Gα(12/13)/MAPK signaling pathway in the priming and activation of NLRP3 inflammasome during cholestatic liver injury.[1]
Biochem/physiol Actions
Adenylate Cyclase Toxin (CyaA) is responsible for inhibiting the phagocytic activities of neutrophils and macrophages by impairing oxidative response and chemotaxis, ultimately leading to cell apoptosis or necrosis. Additionally, ACT can upregulate the expression of MHC class II and costimulatory molecules on dendritic cells, thereby reducing proinflammatory cytokine production.
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Ta pozycja | |||
|---|---|---|---|
| biological source Bordetella pertussis Tohama I | biological source - | biological source - | biological source - |
| specific activity ≥ 50 units/mg protein | specific activity - | specific activity - | specific activity - |
| Gene Information Bordetella pertussis Tohama I ... CyaA(69600712) | Gene Information Bordetella pertussis Tohama I ... ptxA(2665068), ptxB(2665069), ptxC(2665408) | Gene Information - | Gene Information - |
| technique(s) cell culture | mammalian: suitable | technique(s) - | technique(s) - | technique(s) - |
| assay ≥70% | assay - | assay - | assay - |
| suitability suitable for molecular biology | suitability - | suitability - | suitability - |
Klasa składowania
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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